Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate

doi:10.1002/jhet.2302

	Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate
	Mo, Wenyan 1,2; Shi, Yanxia 3; He, Junbo 1,2; Li, Baoju 3; Peng, Hao 1,2; He, Hongwu 1,2
刊名	JOURNAL OF HETEROCYCLIC CHEMISTRY
	2016
卷号	53 期号:1 页码:183-187
ISSN号	0022-152X
DOI	10.1002/jhet.2302
通讯作者	Mo, Wenyan
英文摘要	A series of novel ethyl 4-(methyl or trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates 7a, 7b, 7c, 7d, 7e and 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were synthesized, and their structures were confirmed by IR, H-1-NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a, 7b, and 7e, the compounds bearing fluorine 8g, 8j, and 8q showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 mu g/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.
学科主题	Chemistry, Organic
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000369003300024
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/100854]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China 2.Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Mo, Wenyan,Shi, Yanxia,He, Junbo,et al. Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2016,53(1):183-187.
APA	Mo, Wenyan,Shi, Yanxia,He, Junbo,Li, Baoju,Peng, Hao,&He, Hongwu.(2016).Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate.JOURNAL OF HETEROCYCLIC CHEMISTRY,53(1),183-187.
MLA	Mo, Wenyan,et al."Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate".JOURNAL OF HETEROCYCLIC CHEMISTRY 53.1(2016):183-187.