An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent

	An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent
	Feng JH ; Li XJ ; Pei FK ; Sun GY ; Zhang X ; Liu ML
刊名	magnetic resonance imaging
	2002
卷号	20 期号:5 页码:407-412
关键词	RELAXATION COMPLEXES WATER NANOPARTICLES STABILITY
ISSN号	0730-725x
通讯作者	pei fk
中文摘要	two gadolinium polyoxometalates, k9gdw10o36 and k-11 [gd(pw11o39)(2)], have been evaluated both in vivo and in vitro as candidates for tissue-specific mri contrast agents. t-1-relaxivities of 6.89 mm(-1) . s(-1) for k9gdw10o36 and 5.27 mm(-1) . s(-1) for k-11[gd(pw11o39)(2)] are slightly higher than that of the commercial mri contrast agent (gd-dtpa). both compounds bind with bovine serum albumin and human serum transferrin and favorable liver-specific contrast enhancement in in vivo mri with sprague-dawley rats after i.v. administration has been demonstrated. imaging studies demonstrate that the two agents have a long residence time, showing mr signal enhancement in the liver for more than 40 min, longer than commercially available contrast agents. in vivo and in vitro assays showed that gdw10 and gd(pw11)(2) are promising liver-specific mri contrast agents and gdw10 may be used in the diagnosis of the pathological state. however, with the higher acute toxicity, the two gadolinium polyoxometalates need to be modified and studied further before clinical use.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000177930300006
公开日期	2010-11-03
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/18341]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Feng JH,Li XJ,Pei FK,et al. An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent[J]. magnetic resonance imaging,2002,20(5):407-412.
APA	Feng JH,Li XJ,Pei FK,Sun GY,Zhang X,&Liu ML.(2002).An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent.magnetic resonance imaging,20(5),407-412.
MLA	Feng JH,et al."An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent".magnetic resonance imaging 20.5(2002):407-412.