Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents

	Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents
	Feng JH ; Sun GY ; Pei FK ; Liu ML
刊名	bioorganic & medicinal chemistry
	2003
卷号	11 期号:15 页码:3359-3366
关键词	DIETHYLENETRIAMINEPENTAACETIC ACID BIS(METHYLAMIDE) SERUM-ALBUMIN SOLUTION BLOOD-POOL AGENT MAGNETIC-RESONANCE LANTHANIDE(III) COMPLEXES GADOLINIUM(III) COMPLEXES RELAXATION DYNAMICS LIGAND GDDTPA
ISSN号	0968-0896
通讯作者	pei fk
中文摘要	four neutral gadolinium complexes of diethylenetriaminepentaacetic acid (dtpa)-bisamide derivatives have been synthesized and characterized. their potential application as tissue-specific and low-osmolarity mri contrast agents has been evaluated by in vitro and in vivo experiments. their measured relaxivities in d2o, bovine serum albumin and human serum transferrin solutions showed favorable relaxation ability. in vivo studies have proven that gd(dtpa-bdma), gd(dtpa-bin), and gd(cyclic-dtpa-1,2-pn) could be promising liver-specific mri contrast agents and gd(dtpa-bdma), and gd(cyclic-dtpa-1,2-pn) have favorable renal excretion capability. among them, gd(cyclic-dtpa-1,2-pn) is a more powerful hepatic contrast agent and gd(dtpa-bin) provides the stable imaging contrast for several hours. they also show a lower toxicity.
收录类别	SCI
语种	英语
WOS记录号	WOS:000183935400015
公开日期	2010-09-13
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/17577]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Feng JH,Sun GY,Pei FK,et al. Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents[J]. bioorganic & medicinal chemistry,2003,11(15):3359-3366.
APA	Feng JH,Sun GY,Pei FK,&Liu ML.(2003).Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents.bioorganic & medicinal chemistry,11(15),3359-3366.
MLA	Feng JH,et al."Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents".bioorganic & medicinal chemistry 11.15(2003):3359-3366.