Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds

	Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds
	Li M ; Mondrinos MJ ; Chen X ; Gandhi MR ; Ko FK ; Lelkes PI
刊名	journal of biomedical materials research part a
	2006
卷号	79a 期号:4 页码:963-973
关键词	IN-VITRO EXTRACELLULAR-MATRIX SMOOTH-MUSCLE COLLAGEN CELL NANOFIBER ADHESION POLYMER PROLIFERATION PROTEIN
ISSN号	1549-3296
通讯作者	lelkes pi
中文摘要	in this study, we describe composite scaffolds composed of synthetic and natural materials with physicochemical properties suitable for tissue engineering applications. fibrous scaffolds were co-electrospun from a blend of a synthetic biodegradable polymer (poly(lactic-co-glycolic acid), plga, 10% solution) and two natural proteins, gelatin (denatured collagen, 8% solution) and (x-elastin (20% solution) at ratios of 3:1:2 and 2:2:2 (v/v/v). the resulting plga-gelatin-elastin (pge) fibers were homogeneous in appearance with an average diameter of 380 80 mn, which was considerably smaller than fibers made under identical conditions from the starting materials (plga, 780 +/- 200 nm; gelatin, 447 +/- 1.23 nm; elastin, 1060 170 nm). upon hydration, pge fibers swelled to an average fiber diameter of 963 +/- 132 nm, but did not disintegrate. importantly, pge scaffolds were stable in an aqueous environment without crosslinking, and were more elastic than those made of pure elastin fibers. to investigate the cytocompatibility of pge, we cultured h9c2 rat cardiac myoblasts and rat bone marrow stromal cells (bmscs) on fibrous pge scaffolds. we found that myoblasts grew equally as well or slightly better on the scaffolds than on tissue-culture plastic. microscopic evaluation confirmed that myoblasts reached confluence on the scaffold surfaces while simultaneously growing into the scaffolds.
收录类别	SCI
语种	英语
WOS记录号	WOS:000242360400021
公开日期	2010-08-17
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/16255]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li M,Mondrinos MJ,Chen X,et al. Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds[J]. journal of biomedical materials research part a,2006,79a(4):963-973.
APA	Li M,Mondrinos MJ,Chen X,Gandhi MR,Ko FK,&Lelkes PI.(2006).Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds.journal of biomedical materials research part a,79a(4),963-973.
MLA	Li M,et al."Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds".journal of biomedical materials research part a 79a.4(2006):963-973.