Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells | |
Wang, JZ; Tsumura, H; Shimura, K; Tian, X; Ito, H | |
刊名 | ACTA PHARMACOLOGICA SINICA
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1998-11 | |
卷号 | 19期号:6 |
关键词 | cell cycle 细胞周期 lymphocytic leukemia 淋巴细胞性白血病 cultured tumor cells 培养的肿瘤细胞 spin labels 自旋标记物 podophyllotoxin 鬼臼毒素 etoposide 依托泊苷 |
ISSN号 | 0253-9756 |
其他题名 | Effects of spin labeled derivatives of podophylotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells |
通讯作者 | Wang, JZ (reprint author), Natl Inst Control Pharmaceut & Biol Prod, Dept Biochem, Beijing 100050, Peoples R China. |
中文摘要 | 目的:证实鬼臼毒素自旋标记物GP4和GP7体外对Molt4B细胞周期和大分子合成的抑制作用.方法:MTT、同位素标记法和流式细胞分光光度仪BrdU/DNA分析法.结果:GP4,GP7和依托泊苷(002-100mmol·L-1,48h)抑制细胞生长量效曲线不同,其IC50值分别为0.11,4.7,1.6mmol·L-1,并降低DNA、蛋白质合成.GP4(10mmol·L-112h)增加有丝分裂指数,为对照组的5倍;GP7和依托泊苷都降低有丝分裂指数,分别为对照组的1/3和1/10.GP4主要阻止细胞于G2/M期,而GP7与依托泊苷相似,将细胞阻滞在S和G2期.结论:GP4和GP7抑制Molt4... |
学科主题 | Chemistry;Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000076914200001 |
内容类型 | 期刊论文 |
源URL | [http://202.201.7.4:8080/handle/262010/79696] ![]() |
专题 | 化学化工学院_期刊论文 |
推荐引用方式 GB/T 7714 | Wang, JZ,Tsumura, H,Shimura, K,et al. Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells[J]. ACTA PHARMACOLOGICA SINICA,1998,19(6). |
APA | Wang, JZ,Tsumura, H,Shimura, K,Tian, X,&Ito, H.(1998).Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells.ACTA PHARMACOLOGICA SINICA,19(6). |
MLA | Wang, JZ,et al."Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells".ACTA PHARMACOLOGICA SINICA 19.6(1998). |
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