Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells

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	Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells
	Wang, JZ; Tsumura, H; Shimura, K; Tian, X; Ito, H
刊名	ACTA PHARMACOLOGICA SINICA
	1998-11
卷号	19 期号:6
关键词	cell cycle 细胞周期 lymphocytic leukemia 淋巴细胞性白血病 cultured tumor cells 培养的肿瘤细胞 spin labels 自旋标记物 podophyllotoxin 鬼臼毒素 etoposide 依托泊苷
ISSN号	0253-9756
其他题名	Effects of spin labeled derivatives of podophylotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells
通讯作者	Wang, JZ (reprint author), Natl Inst Control Pharmaceut & Biol Prod, Dept Biochem, Beijing 100050, Peoples R China.
中文摘要	目的：证实鬼臼毒素自旋标记物ＧＰ４和ＧＰ７体外对Ｍｏｌｔ４Ｂ细胞周期和大分子合成的抑制作用．方法：ＭＴＴ、同位素标记法和流式细胞分光光度仪ＢｒｄＵ／ＤＮＡ分析法．结果：ＧＰ４，ＧＰ７和依托泊苷（００２－１００ｍｍｏｌ·Ｌ－１，４８ｈ）抑制细胞生长量效曲线不同，其ＩＣ５０值分别为０．１１，４．７，１．６ｍｍｏｌ·Ｌ－１，并降低ＤＮＡ、蛋白质合成．ＧＰ４（１０ｍｍｏｌ·Ｌ－１１２ｈ）增加有丝分裂指数，为对照组的５倍；ＧＰ７和依托泊苷都降低有丝分裂指数，分别为对照组的１／３和１／１０．ＧＰ４主要阻止细胞于Ｇ２／Ｍ期，而ＧＰ７与依托泊苷相似，将细胞阻滞在Ｓ和Ｇ２期．结论：ＧＰ４和ＧＰ７抑制Ｍｏｌｔ４...
学科主题	Chemistry;Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000076914200001
内容类型	期刊论文
源URL	[http://202.201.7.4:8080/handle/262010/79696]
专题	化学化工学院_期刊论文
推荐引用方式 GB/T 7714	Wang, JZ,Tsumura, H,Shimura, K,et al. Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells[J]. ACTA PHARMACOLOGICA SINICA,1998,19(6).
APA	Wang, JZ,Tsumura, H,Shimura, K,Tian, X,&Ito, H.(1998).Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells.ACTA PHARMACOLOGICA SINICA,19(6).
MLA	Wang, JZ,et al."Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells".ACTA PHARMACOLOGICA SINICA 19.6(1998).