The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques

doi:10.1016/j.virol.2015.10.018

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	The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques
	Zhang, Hui-Ling 1; Liu, Feng-Liang 2; Jin, Ya-Bin 1; Deng, Qing 1; Liu, Bei-Lei 1; Zhuo, Min 1; liu, Xiao-Hui 3; Zheng, Yong-Tang 2; Ling, Fei 1
刊名	VIROLOGY
	2016
卷号	487 页码:222-229
关键词	TRIM5 alpha polymorphism HIV-2ROD SIVmac239 Chinese-origin rhesus macaques Vietnamese-origin cynomolgus macaques
ISSN号	0042-6822
DOI	10.1016/j.virol.2015.10.018
通讯作者	Zhang, Hui-Ling
英文摘要	Because of the difficulty of obtaining Indian-origin rhesus macaques, Chinese-origin rhesus macaques (CR) and Vietnamese-origin cynomolgus macaques (CM) are now used frequently in HIV/AIDS research. Nonetheless, the effects of TRIM5 alpha polymorphism on viral replication in both CR and CM are unclear. To address these questions, we recruited 70 unrelated CR and 40 unrelated CM and studied the effect of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs. We found that 3 polymorphisms, located in the B30.2 domain of CR TRIM5 alpha formed a haplotype and affected HIV-2ROD replication. In addition, we found that the variant Y178H, located in the Coiled-coil domain of CM TRIM5 alpha, affected TRIM5 alpha-mediated HIV-2ROD restriction. Finally, two polymorphisms, located in the Coiled-coil domain, altered anti-SIVmac239 activity in CR. We concluded that, CM TRIM5 alpha polymorphism could alter HIV-2ROD infection; however, a different domain of CR TRIM5 alpha was responsible for restricting different virus replication. (C) 2015 Elsevier Inc. All rights reserved.
学科主题	Virology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000366438500024
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/11573]
专题	植物保护研究所
作者单位	1.S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming, Yunnan, Peoples R China 3.Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100094, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hui-Ling,Liu, Feng-Liang,Jin, Ya-Bin,et al. The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques[J]. VIROLOGY,2016,487:222-229.
APA	Zhang, Hui-Ling.,Liu, Feng-Liang.,Jin, Ya-Bin.,Deng, Qing.,Liu, Bei-Lei.,...&Ling, Fei.(2016).The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques.VIROLOGY,487,222-229.
MLA	Zhang, Hui-Ling,et al."The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques".VIROLOGY 487(2016):222-229.