Interactions Between Markers Can Be Caused by the Dominance Effect of Quantitative Trait Loci

doi:10.1534/genetics.108.092122

	Interactions Between Markers Can Be Caused by the Dominance Effect of Quantitative Trait Loci
	Zhang, Luyan 1,2,3; Li, Huihui 1,2,3; Li, Zhonglai 3; Wang, Jiankang 1,2
刊名	GENETICS
	2008
卷号	180 期号:2 页码:1177-1190
ISSN号	0016-6731
DOI	10.1534/genetics.108.092122
通讯作者	Zhang, Luyan
英文摘要	F-2 populations are commonly used in genetic studies of animals and plants. For simplicity, most quantitative trait locus or loci (QTL) mapping methods have been developed on the basis of populations having two distinct genotypes at each polymorphic marker or gene locus. fit this study, we demonstrate that dominance can cause the interactions between markers and propose an inclusive linear model that includes marker variables and marker interactions so as to completely control both additive and dominance effects of QTL. The proposed linear model is the theoretical basis for inclusive composite-interval QTL mapping (ICIM) for F-2 populations, which consists of two steps: first, the best. regression model is selected by stepwise regression, which approximately identifies markers and marker interactions explaining both additive and dominance variations; second, the interval mapping approach is applied to the phenotypic values adjusted by the regression model selected in the first step. Due to the limited mapping population size, the large number of variables, and multicollinearity between variables, coefficients in the inclusive linear model cannot be accurately determined in the first step. Interval mapping is necessary in the second step to fine tune the QTL to their true positions. The efficiency of including marker interactions in mapping additive and dominance QTL was demonstrated by extensive simulations using three QTL distribution models with two population sizes and an actual rice F-2 population.
学科主题	Genetics & Heredity ; GENETICS & HEREDITY
语种	英语
出版者	GENETICS
WOS记录号	WOS:000260284400039
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/5577]
专题	作物科学研究所_分子生物学系
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing 100081, Peoples R China 2.Chinese Acad Agr Sci, CIMMYT China Off, Beijing 100081, Peoples R China 3.Beijing Normal Univ, Sch Math Sci, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Luyan,Li, Huihui,Li, Zhonglai,et al. Interactions Between Markers Can Be Caused by the Dominance Effect of Quantitative Trait Loci[J]. GENETICS,2008,180(2):1177-1190.
APA	Zhang, Luyan,Li, Huihui,Li, Zhonglai,&Wang, Jiankang.(2008).Interactions Between Markers Can Be Caused by the Dominance Effect of Quantitative Trait Loci.GENETICS,180(2),1177-1190.
MLA	Zhang, Luyan,et al."Interactions Between Markers Can Be Caused by the Dominance Effect of Quantitative Trait Loci".GENETICS 180.2(2008):1177-1190.