On the use of mathematically-derived traits in QTL mapping

doi:10.1007/s11032-011-9580-z

	On the use of mathematically-derived traits in QTL mapping
	Wang, Yu 1,2,3; Li, Huihui 1,2; Zhang, Luyan 1,2; Lu, Wenyan 3; Wang, Jiankang 1,2
刊名	MOLECULAR BREEDING
	2012
卷号	29 期号:3 页码:661-673
关键词	Derived trait Component trait QTL mapping Power analysis
ISSN号	1380-3743
DOI	10.1007/s11032-011-9580-z
通讯作者	Wang, Yu
英文摘要	Mathematically-derived traits from two or more component traits, either by addition, subtraction, multiplication, or division, have been frequently used in genetics and breeding. When used in quantitative trait locus (QTL) mapping, derived traits sometimes show discrepancy with QTL identified for the component traits. We used three QTL distributions and three genetic effects models, and an actual maize mapping population, to investigate the efficiency of using derived traits in QTL mapping, and to understand the genetic and biological basis of derived-only QTL, i.e., QTL identified for a derived trait but not for any component trait. Results indicated that the detection power of the four putative QTL was consistently greater than 90% for component traits in simulated populations, each consisting of 200 recombinant inbred lines. Lower detection power and higher false discovery rate (FDR) were observed when derived traits were used. In an actual maize population, simulations were designed based on the observed QTL distributions and effects. When derived traits were used, QTL detected for both component and derived traits had comparable power, but those detected for component traits but not for derived traits had low detection power. The FDR from subtraction and division in the maize population were higher than the FDR from addition and multiplication. The use of derived traits increased the gene number, caused higher-order gene interactions than observed in component traits, and possibly complicated the linkage relationship between QTL as well. The increased complexity of the genetic architecture with derived traits may be responsible for the reduced detection power and the increased FDR. Derived-only QTL identified in practical genetic populations can be explained either as minor QTL that are not significant in QTL mapping of component traits, or as false positives.
学科主题	Agronomy ; Plant Sciences ; Genetics & Heredity ; Horticulture ; AGRONOMY ; GENETICS & HEREDITY ; HORTICULTURE ; PLANT SCIENCES
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000300778000009
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/5191]
专题	作物科学研究所_分子生物学系
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing 100081, Peoples R China 2.Chinese Acad Agr Sci, CIMMYT China, Beijing 100081, Peoples R China 3.Shenyang Agr Univ, Coll Agron, Liaoning 110161, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yu,Li, Huihui,Zhang, Luyan,et al. On the use of mathematically-derived traits in QTL mapping[J]. MOLECULAR BREEDING,2012,29(3):661-673.
APA	Wang, Yu,Li, Huihui,Zhang, Luyan,Lu, Wenyan,&Wang, Jiankang.(2012).On the use of mathematically-derived traits in QTL mapping.MOLECULAR BREEDING,29(3),661-673.
MLA	Wang, Yu,et al."On the use of mathematically-derived traits in QTL mapping".MOLECULAR BREEDING 29.3(2012):661-673.