Genome-wide meta-analysis of maize heterosis reveals the potential role of additive gene expression at pericentromeric loci | |
Thiemann, Alexander1; Fu, Junjie2; Seifert, Felix1; Grant-Downton, Robert T.3; Schrag, Tobias A.4; Pospisil, Heike5; Frisch, Matthias6; Melchinger, Albrecht E.4; Scholten, Stefan1,4 | |
刊名 | BMC PLANT BIOLOGY |
2014 | |
卷号 | 14页码:- |
关键词 | Heterosis Maize QTL Grain yield Additive gene expression Haplotype |
ISSN号 | 1471-2229 |
DOI | 10.1186/1471-2229-14-88 |
通讯作者 | Thiemann, Alexander |
英文摘要 | Background: The identification of QTL involved in heterosis formation is one approach to unravel the not yet fully understood genetic basis of heterosis - the improved agronomic performance of hybrid F1 plants compared to their inbred parents. The identification of candidate genes underlying a QTL is important both for developing markers and determining the molecular genetic basis of a trait, but remains difficult owing to the large number of genes often contained within individual QTL. To address this problem in heterosis analysis, we applied a meta-analysis strategy for grain yield (GY) of Zea mays L. as example, incorporating QTL-, hybrid field-, and parental gene expression data.Results: For the identification of genes underlying known heterotic QTL, we made use of tight associations between gene expression pattern and the trait of interest, identified by correlation analyses. Using this approach genes strongly associated with heterosis for GY were discovered to be clustered in pericentromeric regions of the complex maize genome. This suggests that expression differences of sequences in recombination-suppressed regions are important in the establishment of heterosis for GY in F1 hybrids and also in the conservation of heterosis for GY across genotypes. Importantly functional analysis of heterosis-associated genes from these genomic regions revealed over-representation of a number of functional classes, identifying key processes contributing to heterosis for GY. Based on the finding that the majority of the analyzed heterosis-associated genes were addtitively expressed, we propose a model referring to the influence of cis-regulatory variation on heterosis for GY by the compensation of fixed detrimental expression levels in parents.Conclusions: The study highlights the utility of a meta-analysis approach that integrates phenotypic and multi-level molecular data to unravel complex traits in plants. It provides prospects for the identification of genes relevant for QTL, and also suggests a model for the potential role of additive expression in the formation and conservation of heterosis for GY via dominant, multigenic quantitative trait loci. Our findings contribute to a deeper understanding of the multifactorial phenomenon of heterosis, and thus to the breeding of new high yielding varieties. |
学科主题 | Plant Sciences ; PLANT SCIENCES |
语种 | 英语 |
出版者 | BIOMED CENTRAL LTD |
WOS记录号 | WOS:000335346500003 |
内容类型 | 期刊论文 |
源URL | [http://111.203.20.206/handle/2HMLN22E/4904] |
专题 | 作物科学研究所_分子生物学系 |
作者单位 | 1.Univ Hamburg, Bioctr Klein Flottbek, D-22609 Hamburg, Germany 2.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China 3.Univ Oxford, Dept Plant Sci, Oxford OX1 3RB, England 4.Univ Hohenheim, Inst Plant Breeding Seed Sci & Populat Genet, D-70599 Stuttgart, Germany 5.Tech Univ Appl Sci Wildau, Dept Bioinformat, D-15745 Wildau, Germany 6.Univ Giessen, Inst Agron & Plant Breeding 2, D-35392 Giessen, Germany |
推荐引用方式 GB/T 7714 | Thiemann, Alexander,Fu, Junjie,Seifert, Felix,et al. Genome-wide meta-analysis of maize heterosis reveals the potential role of additive gene expression at pericentromeric loci[J]. BMC PLANT BIOLOGY,2014,14:-. |
APA | Thiemann, Alexander.,Fu, Junjie.,Seifert, Felix.,Grant-Downton, Robert T..,Schrag, Tobias A..,...&Scholten, Stefan.(2014).Genome-wide meta-analysis of maize heterosis reveals the potential role of additive gene expression at pericentromeric loci.BMC PLANT BIOLOGY,14,-. |
MLA | Thiemann, Alexander,et al."Genome-wide meta-analysis of maize heterosis reveals the potential role of additive gene expression at pericentromeric loci".BMC PLANT BIOLOGY 14(2014):-. |
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