Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy

	Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy
	Liao PQ ; Wei L ; Zhang XY ; Li XJ ; Wu HF ; Wu YJ ; Ni JZ ; Pei FK
刊名	analytical biochemistry
	2007
卷号	364 期号:2 页码:112-121
关键词	MAGNETIC-RESONANCE-SPECTROSCOPY PATTERN-RECOGNITION METHODS ALPHA-NAPHTHYLISOTHIOCYANATE NMR-SPECTROSCOPY URINE LIVER CLASSIFICATION PLASMA MOUSE LANTHANIDES
ISSN号	0003-2697
通讯作者	li xj
中文摘要	metabolic profiling of serum from gadolinium chloride (gdcl3, 10 and 50 mg/kg body weight, intraperitoneal [i.p.])-treated rats was investigated by the nmr spectroscopic-based metabonomic strategy. serum samples were collected at 48, 96, and 168 h postdose (p.d.) after exposure to gdcl3. h-1 nmr spectra of serum were analyzed by pattern recognition using principal components analysis. the studies showed that there was a dose-related biochemical effect of gdcl3 treatment on the levels of a range of low-molecular weight compounds in serum. the liver damage induced by gdcl3 was characterized by the elevation of lactate, pyruvate, and creatine as well as the decrease of branched-chain amino acids (valine and isoleucine), alanine, glucose, and trimethylamine-n-oxide concentration in serum samples. the biochemical effects of gdcl3 in rats could be consulted when evaluating the biochemical profile of gadolinium-containing compounds that are being developed for nuclear magnetic resonance imaging.
收录类别	SCI
语种	英语
WOS记录号	WOS:000245960400003
公开日期	2010-07-13
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/14125]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liao PQ,Wei L,Zhang XY,et al. Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy[J]. analytical biochemistry,2007,364(2):112-121.
APA	Liao PQ.,Wei L.,Zhang XY.,Li XJ.,Wu HF.,...&Pei FK.(2007).Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy.analytical biochemistry,364(2),112-121.
MLA	Liao PQ,et al."Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy".analytical biochemistry 364.2(2007):112-121.