Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography

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	Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography
	Liu, Boyan 1,2; Dong, Beitao 1,2; Yuan, Xiaofan1 ; Guo, Yuanheng 1,2; Zhang, Lijun 1,2; Zhao, Bing 1
刊名	SEPARATION SCIENCE AND TECHNOLOGY
	2017
卷号	52 期号:6 页码:1114-1121
关键词	Chlorogenic acid Eupatorium adenophorum Spreng macroporous resin 9-oxo-10 11-dehydroageraphorone polyamide resin
ISSN号	0149-6395
英文摘要	An efficient method for simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum was developed. The entire procedure consisted of two separation steps. The first step was enrichment of chlorogenic acid from the crude extract by NKA-II macroporous resin. The purity of chlorogenic acid increased from 5.3% to 20.9% with a recovery of 88.7%. Subsequently, polyamide resin was used to achieve a higher purity. After the polyamide resin treatment, the main toxin 9-oxo-10,11-dehydroageraphorone was removed and the purity of chlorogenic acid reached 86.5% with a recovery of 84.8%. It provided a new way for the utilization of E. adenophorum.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Engineering, Chemical
研究领域[WOS]	Chemistry ; Engineering
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; COUNTER-CURRENT CHROMATOGRAPHY ; POLYAMIDE RESIN ; MACROPOROUS RESINS ; AGERATINA-ADENOPHORA ; CAFFEIC ACID ; NATURAL-PRODUCTS ; PURIFICATION ; ADSORPTION ; EXTRACT
收录类别	SCI
语种	英语
WOS记录号	WOS:000399643200014
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/22477]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Div Biorefinery Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Boyan,Dong, Beitao,Yuan, Xiaofan,et al. Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography[J]. SEPARATION SCIENCE AND TECHNOLOGY,2017,52(6):1114-1121.
APA	Liu, Boyan,Dong, Beitao,Yuan, Xiaofan,Guo, Yuanheng,Zhang, Lijun,&Zhao, Bing.(2017).Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography.SEPARATION SCIENCE AND TECHNOLOGY,52(6),1114-1121.
MLA	Liu, Boyan,et al."Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography".SEPARATION SCIENCE AND TECHNOLOGY 52.6(2017):1114-1121.