Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes

	Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes
	Kim SH ; Lee SH ; Tian HY ; Chen XS ; Park TG
刊名	journal of drug targeting
	2009
卷号	17 期号:4 页码:311-317
关键词	POLYELECTROLYTE COMPLEX MICELLES MEDIATED DELIVERY RNA INTERFERENCE GENE DELIVERY PLASMID DNA GLYCOL) THERAPY GROWTH COPOLYMERS PEI
ISSN号	1061-186x
通讯作者	park tg
中文摘要	a polymeric gene carrier was developed to deliver vascular endothelial growth factor (vegf) small interfering rna (sirna) for prostate cancer cells in a target-specific manner. prostate cancer-binding peptide (pcp) was conjugated with polyethylenimine (pei) via a poly(ethylene glycol) (peg) linker (pei-peg-pcp). the pei-peg-pcp conjugate could effectively condense sirna to form stable polyelectrolyte complexes (polyplexes) with an average diameter of approximately 150 nm in an aqueous solution. vegf sirna/pei-peg-pcp polyplexes exhibited significantly higher vegf inhibition efficiency than pcp-unmodified polycationic carriers (pei-peg or pei) in human prostate carcinoma cells (pc-3 cells). the enhanced gene silencing activity of vegf sirna/pei-peg-pcp was maintained even under serum conditions, owing to the steric stabilization of the polyplexes with hydrophilic peg grafts. confocal microscopic studies revealed that the sirna/pei-peg-pcp polyplexes were delivered into pc-3 cells in a pcp ligand-specific manner.
收录类别	SCI
语种	英语
WOS记录号	WOS:000266593800007
公开日期	2010-06-18
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/12935]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kim SH,Lee SH,Tian HY,et al. Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes[J]. journal of drug targeting,2009,17(4):311-317.
APA	Kim SH,Lee SH,Tian HY,Chen XS,&Park TG.(2009).Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes.journal of drug targeting,17(4),311-317.
MLA	Kim SH,et al."Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes".journal of drug targeting 17.4(2009):311-317.