Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA

	Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA
	Xu XY ; Zhang XF ; Wang XH ; Li YX ; Jing XB
刊名	polymers for advanced technologies
	2009
卷号	20 期号:11 页码:843-848
关键词	AMPHIPHILIC BLOCK-COPOLYMERS WATER-SOLUBLE PRODRUGS MACROMOLECULAR THERAPEUTICS POLY(ETHYLENE GLYCOL) VASCULAR-PERMEABILITY PLGA NANOPARTICLES ANTITUMOR-ACTIVITY POLYMERIC MICELLE SOLID TUMOR IN-VITRO
ISSN号	1042-7147
通讯作者	li yx
中文摘要	paclitaxel-loaded poly(ethylene glycol)-b-poly(l-lactide (la)) (peg-pla) micelles were prepared by two methods. one is physical encapsulation of paclitaxel in micelles composed of a peg-pla block copolymer and the other is based on a peg-pla-paclitaxel conjugate, abbreviated as "conjugate micelles" their physicochemical characteristics, e.g. critical micelle concentration (cmc), morphology, and micelle size distribution were then evaluated by means of fluorescence spectroscopy, scanning electron microscopy (sem), and dynamic light scattering (dls). the results show that the cmc of peg-pla-paclitaxel and peg-pla are 6.31 x 10(4) and 1.78 x 10(-3) g l-1, respectively. both micelles assume a spherical shape with comparable diameters and have unimodal size distribution. moreover, in vitro drug delivery behavior was studied by high performance liquid chromatography (hplc). the antitumor activity of the paclitaxel-loaded micelles against human liver cancer h7402 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) method.
收录类别	SCI
语种	英语
WOS记录号	WOS:000271051900005
公开日期	2010-06-18
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/12921]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xu XY,Zhang XF,Wang XH,et al. Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA[J]. polymers for advanced technologies,2009,20(11):843-848.
APA	Xu XY,Zhang XF,Wang XH,Li YX,&Jing XB.(2009).Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA.polymers for advanced technologies,20(11),843-848.
MLA	Xu XY,et al."Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA".polymers for advanced technologies 20.11(2009):843-848.