Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis

	Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis
	Lu TC ; Sun J ; Chen XX ; Zhang PB ; Jing XB
刊名	macromolecular bioscience
	2009
卷号	9 期号:11 页码:1059-1068
关键词	BLOCK-COPOLYMER MICELLES ANTICANCER DRUG-DELIVERY BRAIN ENDOTHELIAL-CELLS POLYMERIC MICELLES TUMOR-CELLS CANCER-CELLS IN-VITRO DOXORUBICIN NANOPARTICLES PH
ISSN号	1616-5187
通讯作者	jing xb
中文摘要	a folate-conjugated copolymer peg-pla-pll/folate was synthesized and mixed with pure peg-pla-pll and a fluorescent model drug mfitc to prepare folate-conjugated micelles. the distribution of micelles was studied on cancer-cell-bearing mice via frozen slicing. the results show that mfitc is successfully encapsulated into folate(+) and folate(-)micelles; peg-pla-pll micelles the latter can be internalized by both hela and cho cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by hela cells than by cho cells. the folate(-)micelles showed retention in both organs and tumors. the folate(+)micelles are a promising active targeting drug delivery system for fr over-expressing cells and they accumulate in tumor beds.
收录类别	SCI
语种	英语
WOS记录号	WOS:000271990000002
公开日期	2010-06-18
内容类型	期刊论文
源URL	[http://202.98.16.49/handle/322003/12917]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Lu TC,Sun J,Chen XX,et al. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis[J]. macromolecular bioscience,2009,9(11):1059-1068.
APA	Lu TC,Sun J,Chen XX,Zhang PB,&Jing XB.(2009).Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis.macromolecular bioscience,9(11),1059-1068.
MLA	Lu TC,et al."Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis".macromolecular bioscience 9.11(2009):1059-1068.