Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin | |
Wang XH ; Song YJ ; Ren JS ; Qu XG | |
刊名 | plos one
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2009 | |
卷号 | 4期号:8页码:文献编号:e6665 |
ISSN号 | 1932-6203 |
通讯作者 | wang xh |
中文摘要 | cyclin a(2) is critical for the initiation of dna replication, transcription and cell cycle regulation. cumulative evidences indicate that the deregulation of cyclin a(2) is tightly linked to the chromosomal instability, neoplastic transformation and tumor proliferation. here we report that treatment of chronic myelogenous leukaemia k562 cells with doxorubicin results in an accumulation of cyclin a(2) and follows by induction of apoptotic cell death. to investigate the potential preclinical relevance, k562 cells were transiently transfected with the sirna targeting cyclin a(2) by functionalized single wall carbon nanotubes. knocking down the expression of cyclin a(2) in k562 cells suppressed doxorubicin-induced growth arrest and cell apoptosis. upon administration with doxorubicin, k562 cells with reduced cyclin a(2) showed a significant decrease in erythroid differentiation, and a small fraction of cells were differentiated along megakaryocytic and monocyte-macrophage pathways. the results demonstrate the pro-apoptotic role of cyclin a(2) and suggest that cyclin a(2) is a key regulator of cell differentiation. |
收录类别 | 其它国际期刊论文 |
语种 | 英语 |
WOS记录号 | WOS:000269075600002 |
公开日期 | 2010-06-18 |
内容类型 | 期刊论文 |
源URL | [http://202.98.16.49/handle/322003/12713] ![]() |
专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
推荐引用方式 GB/T 7714 | Wang XH,Song YJ,Ren JS,et al. Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin[J]. plos one,2009,4(8):文献编号:e6665. |
APA | Wang XH,Song YJ,Ren JS,&Qu XG.(2009).Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin.plos one,4(8),文献编号:e6665. |
MLA | Wang XH,et al."Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin".plos one 4.8(2009):文献编号:e6665. |
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