Amplitude of low-frequency fluctuations in first-episode, drug-naive depressive patients: A 5-year retrospective study

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	Amplitude of low-frequency fluctuations in first-episode, drug-naive depressive patients: A 5-year retrospective study
	Zhang, Kerang 1; Liu, Zhifen 1; Cao, Xiaohua 1; Yang, Chunxia 1; Xu, Yong 1; Xu, Ting 2,3,4; Xu, Cheng 5; Yang, Zhi 2,3,4
刊名	PLOS ONE
	2017-04-06
卷号	12 期号:4
ISSN号	1932-6203
英文摘要	Despite different treatments and courses of illness, depressive symptoms appear similar in bipolar disorder (BD) and major depressive disorder (MDD), causing BD with an onset of depressive episode being frequently misdiagnosed as MDD, and leading to inappropriate treatment and poor clinical outcomes. Therefore, there is an urgent need to explore underlying neural basis to distinguish BD from MDD. The medical records of 80 first-episode, drug-naive depressive patients with an initial diagnosis of MDD and illness duration of at least 5 years were reviewed retrospectively for this study. Fourteen bipolar depressed patients with a diagnosis conversion from MDD to BD, 14 patients with diagnosis of MDD, and 14 healthy subjects demographically matched with the BD group, were selected to participate in the study. Firstly, we examined whether there were differences among the three groups in whole brain fALFF during resting state. Secondly, clusters showing group differences in fALFF in any two groups were chosen as regions of interest (ROI) and then correlation between clinical features and fALFF values of ROIs were calculated. The BD group showed increased fALFF in bilateral putamen relative to both the MDD group and controls, while the MDD group exhibited decreased fALFF in left superior frontal gyrus (SFG) relative to both the BD group and controls (p < 0.05, corrected). Positive correlations between abnormality in the putamen and symptom severity were observed (significant for the MDD group, p = 0.043; marginally significant for the BD group, p = 0.060/0.076). These results implicate that abnormalities of key regions in the striatum and prefrontal areas may be trait markers for BD and MDD.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	RESTING-STATE FMRI ; VOXEL-BASED MORPHOMETRY ; COMORBIDITY SURVEY REPLICATION ; BIPOLAR DISORDER ; MAJOR DEPRESSION ; FUNCTIONAL CONNECTIVITY ; UNIPOLAR DEPRESSION ; NEURAL RESPONSE ; TREATMENT-RESISTANT ; FACIAL EXPRESSIONS
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000399371900020
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/21649]
专题	心理研究所_中国科学院行为科学重点实验室
作者单位	1.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China 2.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Beijing, Peoples R China 5.Shanxi Prov Hosp, Dept Radiol, Taiyuan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Kerang,Liu, Zhifen,Cao, Xiaohua,et al. Amplitude of low-frequency fluctuations in first-episode, drug-naive depressive patients: A 5-year retrospective study[J]. PLOS ONE,2017,12(4).
APA	Zhang, Kerang.,Liu, Zhifen.,Cao, Xiaohua.,Yang, Chunxia.,Xu, Yong.,...&Yang, Zhi.(2017).Amplitude of low-frequency fluctuations in first-episode, drug-naive depressive patients: A 5-year retrospective study.PLOS ONE,12(4).
MLA	Zhang, Kerang,et al."Amplitude of low-frequency fluctuations in first-episode, drug-naive depressive patients: A 5-year retrospective study".PLOS ONE 12.4(2017).