Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)

	Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)
	Meng, Lingjie1,2 ; Du, Yishuai 1; Liu, Pengfei 1,2; Li, Xian 1; Liu, Ying3
刊名	FISH & SHELLFISH IMMUNOLOGY
	2017-05-01
卷号	64 页码:260-269
关键词	Quorum sensing AI-2 LuxS Aeromonas salmonicida Virulence Surface property A-layer Innate immnuity Salmo solar L
英文摘要	Quorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A. salmonicida. The consequences demonstrated that wild type A. salmonicida exhibited Al-2 activity and luxS defective mutant strain fail to produce Al-2 signals. Furthermore, it was suggested that luxS deficiency could impact bacterial morphology, surface properties and virulence dramatically. Challenge experiment showed a tendency that immune factors expressed earlier when Atlantic salmon was infected with AluxS strain. Overall, we hypothesis that Al-2 quorum sensing could regulate the expression of A-layer protein coding gene vapA, and then influence bacterial survival ability when suffered from attack of the host immune system. Though additional studies are warranted, our study will supply a new thinking to control the damage caused by A. salmonicida. (C) 2017 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000401217900028
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/136852]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Dalian Ocean Univ, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Meng, Lingjie,Du, Yishuai,Liu, Pengfei,et al. Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:260-269.
APA	Meng, Lingjie,Du, Yishuai,Liu, Pengfei,Li, Xian,&Liu, Ying.(2017).Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L).FISH & SHELLFISH IMMUNOLOGY,64,260-269.
MLA	Meng, Lingjie,et al."Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)".FISH & SHELLFISH IMMUNOLOGY 64(2017):260-269.