Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020
	Liang, X; Nong, XH; Huang, ZH; Qi, SH
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2017
卷号	65 期号:25 页码:5114-5121
关键词	deep-sea-derived fungus Simplicillium obclavatum peptide antifungal antiviral structure-bioactivity relationship
通讯作者	shuhuaqi@scsio.ac.cn
中文摘要	A new linear peptide simplicilliumtide I (1) and four new cyclic peptides simplicilliumtides JM (25) together with known analogues verlamelins A and B (6 and 7) were isolated from the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were further confirmed by chemical structural modification, Marfeys and Moshers methods. Compounds 2, 6, and 7 showed significant antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also had obvious antiviral activity toward HSV-1 with IC50 values of 14.0, 16.7, and 15.6 mu M, respectively. The structurebioactivity relationship of this type of cyclic peptide was also discussed. This is the first time to discuss the effects of the lactone linkage and the substituent group of the fatty acid chain fragment on the bioactivity of this type of cyclic peptides. This is also the first time to report the antiviral activity of these cyclic peptides.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16299]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Liang, X,Nong, XH,Huang, ZH,et al. Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(25):5114-5121.
APA	Liang, X,Nong, XH,Huang, ZH,&Qi, SH.(2017).Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,65(25),5114-5121.
MLA	Liang, X,et al."Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.25(2017):5114-5121.