Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth

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	Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth
	Wang, J; Yao, QF; Amin, M; Nong, XH; Zhang, XY; Qi, SH
刊名	JOURNAL OF ANTIBIOTICS
	2017
卷号	70 期号:6 页码:763-770
通讯作者	shuhuaqi@scsio.ac.cn
中文摘要	Penicillenols (Al, A2, Bl, B2, Cl and C2) were isolated from Aspergillus restrictus DFFSCS006, and could differentially inhibit biofilm formation and eradicate pre-developed biofilms of Candida albicans. Their structure bioactivity relationships suggested that the saturation of hydrocarbon chain at C-8, R-configuration of C-5 and trans-configuration of the double bond between C-5 and C-6 of pyrrolidine-2,4-dione unit were important for their anti-biofilm activities. Penicillenols A2 and B1 slowed the hyphal growth and suppressed the transcripts of hypha specific genes HWP1, ALS1, ALS3, ECE1 and SAP4. Moreover, penicillenols A2 and B1 were found to act synergistically with amphotericin B against C. albicans biofilm formation.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16292]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wang, J,Yao, QF,Amin, M,et al. Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth[J]. JOURNAL OF ANTIBIOTICS,2017,70(6):763-770.
APA	Wang, J,Yao, QF,Amin, M,Nong, XH,Zhang, XY,&Qi, SH.(2017).Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth.JOURNAL OF ANTIBIOTICS,70(6),763-770.
MLA	Wang, J,et al."Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth".JOURNAL OF ANTIBIOTICS 70.6(2017):763-770.