Construction of hollow DNA/PLL microcapsule as a dual carrier for controlled delivery of DNA and drug

	Construction of hollow DNA/PLL microcapsule as a dual carrier for controlled delivery of DNA and drug
	Wang ZJ ; Qian L ; Wang XL ; Yang F ; Yang XR
刊名	colloids and surfaces a-physicochemical and engineering aspects
	2008
卷号	326 期号:1-2 页码:29-36
关键词	POLYELECTROLYTE MULTILAYER CAPSULES BIODEGRADABLE MICROCAPSULES GENE-THERAPY CARBONATE MICROPARTICLES MEDIATED TRANSFECTION CONTROLLED-RELEASE NUCLEIC-ACIDS NANOPARTICLES FILMS ENCAPSULATION
ISSN号	0927-7757
通讯作者	yang xr
中文摘要	dna/poly-l-lysine (pll) capsules were constructed through a layer-by-layer (lbl) self-assembly of dna and pll on caco3 microparticles, and then used as dual carriers for dna and drug after dissolution of carbonate cores. the permeability of dna/pll microcapsules was investigated with fluorescence probes with different molecular weights by confocal microscopy. the result revealed that the fluorescence probes were able to penetrate the capsule walls even its molecular weight up to 150 kda. the resultant capsules were used to load drug model molecules-fluorescein isothiocyanate (fitc)-dextran (4 kda) via spontaneous deposition mechanism.
收录类别	SCI
语种	英语
WOS记录号	WOS:000259523100005
公开日期	2010-04-14
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/10557]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang ZJ,Qian L,Wang XL,et al. Construction of hollow DNA/PLL microcapsule as a dual carrier for controlled delivery of DNA and drug[J]. colloids and surfaces a-physicochemical and engineering aspects,2008,326(1-2):29-36.
APA	Wang ZJ,Qian L,Wang XL,Yang F,&Yang XR.(2008).Construction of hollow DNA/PLL microcapsule as a dual carrier for controlled delivery of DNA and drug.colloids and surfaces a-physicochemical and engineering aspects,326(1-2),29-36.
MLA	Wang ZJ,et al."Construction of hollow DNA/PLL microcapsule as a dual carrier for controlled delivery of DNA and drug".colloids and surfaces a-physicochemical and engineering aspects 326.1-2(2008):29-36.