Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

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	Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies
	Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业)
刊名	MedChemComm
	2011
卷号	2 期号:4 页码:315-320
其他题名	基于二苯基丁基哌啶结构的细胞自吞噬诱导剂: 合成与构效关系研究
英文摘要	A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure-activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF(3) group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c0md00236d
语种	英语
WOS记录号	WOS:000290697800012
公开日期	2013-01-09
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/11088]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Chen G,Xia HG,Cai Y,et al. Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies[J]. MedChemComm,2011,2(4):315-320.
APA	Chen G,Xia HG,Cai Y,Ma DW,Yuan JY,&Yuan CY.(2011).Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies.MedChemComm,2(4),315-320.
MLA	Chen G,et al."Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies".MedChemComm 2.4(2011):315-320.