Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents

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	Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents
	Hou XL(侯雪龙) ; Li BF(李冰峰) ; Dai LX(戴立信)
刊名	Tetrahedron-Asymmetry
	1999
卷号	10 页码:2319-2326
ISSN号	0957-4166
其他题名	新型环氧丙胺单一对映体的合成：发散型合成光学纯的贤上腺素β－阻断剂
通讯作者	侯雪龙
英文摘要	The chiral building block (S)-N-benzyl-N-isopropyl-2,3-epoxypropylamine is obtained by means of chlorohydroxylation of allylamine, followed by Jacobsen's hydrolytic kinetic resolution with water. A concise, divergent five-step synthesis of three β-adrenergic blocking agents in high enantiomeric excess using (S)-N_benzyl-N-isopropyl-2,3-epoxypropylamine as the key intermediate is described.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/S0957-4166(99)00248-7
语种	英语
公开日期	2013-02-19
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/15813]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Hou XL,Li BF,Dai LX. Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents[J]. Tetrahedron-Asymmetry,1999,10:2319-2326.
APA	侯雪龙,李冰峰,&戴立信.(1999).Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents.Tetrahedron-Asymmetry,10,2319-2326.
MLA	侯雪龙,et al."Synthesis of novel and enantiomerically pure epoxypropylamine: a divergent route to the chiral β-adrenergic blocking agents".Tetrahedron-Asymmetry 10(1999):2319-2326.