Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity

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	Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity
	Ma SM(麻生明) ; Lu Z(陆展)
刊名	Adv. Synth. Catal.
	2006
卷号	348 期号:14 页码:1894-1898
ISSN号	1615-4150
其他题名	Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity
通讯作者	麻生明
英文摘要	A highly regio- and stereoselective syn-carbometalation of terminal secondary or tertiary propargylic alcohols with primary alkyl Grignard reagents in toluene or phenylmagnesium bromide in Et2O was developed, in which the alkyl or phenyl group from the Grignard reagents is introduced into the terminal position of the alcohols. The organometallic intermediate formed may be used directly for the coupling reaction with organic halides. Upon treatment with I-2 after the carbometalation, iodides may be obtained, which may undergo Sonogashira coupling reaction and highly stereoselective Novozym-435-catalyzed kinetic resolution to afford the optically active products.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/adsc.200606004
语种	英语
公开日期	2013-01-16
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/12054]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Ma SM,Lu Z. Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity[J]. Adv. Synth. Catal.,2006,348(14):1894-1898.
APA	麻生明,&陆展.(2006).Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity.Adv. Synth. Catal.,348(14),1894-1898.
MLA	麻生明,et al."Copper(I)-mediated highly stereoselective syn-carbometalation of secondary or tertiary propargylic alcohols with primary Grignard reagents in tolune with a high linear regioselectivity alcohols; regioselectivity".Adv. Synth. Catal. 348.14(2006):1894-1898.