Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands

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	Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands
	Li L(李龙); Hu JL; Shi XH(施兴华); Shao YF(邵颖峰); Song F(宋凡)
刊名	SOFT MATTER
	2017-06-21
卷号	13 期号:23 页码:4294-4304
ISSN号	1744-683X
中文摘要	Gaining insights into the binding of membrane-anchored receptors and ligands that mediate cell adhesion and signal transduction is of great significance for understanding numerous physiological processes driven by intercellular communication. Lipid rafts microdomains in cell membranes enriched in cholesterol and saturated lipids such as sphingomyelin are believed to serve as the essential platforms to recruit protein molecules for biological functions. An important question remains how the lipid rafts affect the binding constant of membrane-anchored receptors and ligands. We have investigated the adhesion of multicomponent membranes by using Monte Carlo simulations of a mesoscopic model with biologically relevant parameters. We find that the preferential partitioning of membrane-anchored receptor and ligand proteins in the lipid rafts significantly increases the binding constant of those proteins in cooperation with the shape fluctuations of the membranes caused by thermal excitations. The binding constant can even be greater than that of the same receptors and ligands anchored to two apposing supported planar membranes without shape fluctuations. The membrane shape fluctuations facilitate the binding of the anchored receptors and ligands in contrast to the case of homogeneous membranes. Our results suggest that cells might regulate the binding of membrane-anchored receptor and ligand proteins by modulating the properties of lipid rafts such as area fraction size and the affinity of rafts to the proteins.
类目[WOS]	Chemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
研究领域[WOS]	Chemistry ; Materials Science ; Physics ; Polymer Science
关键词[WOS]	2-DIMENSIONAL DISSOCIATION-CONSTANT ; CELL-ADHESION MOLECULES ; LATERAL DIFFUSION ; CONTACT AREA ; CATCH BONDS ; KINETICS ; TCR ; INSIGHTS ; ROUGHNESS ; PROTEINS
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000403433600012
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/60527]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Li L,Hu JL,Shi XH,et al. Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands[J]. SOFT MATTER,2017,13(23):4294-4304.
APA	李龙,Hu JL,施兴华,邵颖峰,&宋凡.(2017).Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands.SOFT MATTER,13(23),4294-4304.
MLA	李龙,et al."Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands".SOFT MATTER 13.23(2017):4294-4304.