Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples

	Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples
	Zhang, Shijuan 1,2; Ji, Zhongyin 3; Sun, Zhiwei 1,2; Li, Mingshuang 1; Sheng, Cuncun 1; Yue, Mingbo 1; Yu, Yanxin 1; Chen, Guang 1,2; You, Jinmao 1,2,3
刊名	talanta
	2017-05-01
卷号	166 页码:255-261
关键词	Stable isotope labeling PFCA Serum Fluorescence
英文摘要	a new stable isotope labeling (sil) reagent pair, 10-methyl-acridone-2-sulfonohydrazide (mash) and its deuterated counterpart d(3)-mash was synthesized and successfully applied to the analysis of perfluorinated carboxylic acids (pfcas) in serum samples. the limits of detection (lods) were in the range of 0.07-0.42 mu g/l, and the limits of quantitation (loqs) were in the range of 0.25-1.38 mu g/l. besides ionization enhancing effect, mash also showed excellent fluorescence property. therefore, the mass spectrometer operation cost was greatly lowered by carrying out parameter optimization experiments on hplc which is easier to operate and maintain. the sil strategy was confirmed to be effective in reducing matrix effect. the developed multiple reaction monitoring (mrm) condition of pfcas was also suitable for other carboxylic acid due to the introduction of mash which is more prone to fragmentation than the analytes. with the mrm conditions obtained from pfcas, fatty acids were also found in serum samples. this feature made the proposed method show powerful potential in the identification of acidic compounds in complex samples in the absence of corresponding standard.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, analytical
研究领域[WOS]	chemistry
关键词[WOS]	solid-phase extraction ; free fatty-acid ; quantitative-analysis ; biological samples ; aquatic products ; derivatization ; enhancement ; ionization ; strategy ; plasma
收录类别	SCI
语种	英语
WOS记录号	WOS:000395839700035
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6828]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Qufu Normal Univ, Shandong Province Key Lab Life Organ Analy, Jinan, Peoples R China 2.Qufu Normal Univ, Kye Lab Pharm Intermed & Anal, Jinan, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shijuan,Ji, Zhongyin,Sun, Zhiwei,et al. Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples[J]. talanta,2017,166:255-261.
APA	Zhang, Shijuan.,Ji, Zhongyin.,Sun, Zhiwei.,Li, Mingshuang.,Sheng, Cuncun.,...&You, Jinmao.(2017).Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples.talanta,166,255-261.
MLA	Zhang, Shijuan,et al."Stable isotope labeling assisted liquid chromatography-tandem mass spectrometry for the analysis of perfluorinated carboxylic acids in serum samples".talanta 166(2017):255-261.