题名 | 呼吸道合胞病毒感染动物模型的建立及应用; Establishment and Application of Respiratory Syncytial Virus Animal Model |
作者 | 詹炉停 |
答辩日期 | 2017-03-24 ; 2016-05-23 |
导师 | 郑子峥 |
关键词 | 呼吸道合胞病毒 动物模型 肺炎支气管炎 中和抗体预防性评估 RSV animal model pneumonia and bronchitis prophylaxitic potential evaluation |
英文摘要 | 人呼吸道合胞病毒(HumanRespiratorySyncytiaVirus,hRSV)是全球范围内引起下呼吸道感染主要病原体之一。其感染人群年龄分布广,新生儿与老年人是主要高危人群。据报道,几乎所有小于2周岁婴幼儿都有RSV感染经历,婴幼儿发病住院率高达2.5-4%。RSV引起大于65周岁的老年人感染率为3-4%,病死率约为2%。早产儿、先天性心脏病、先天性支气管及肺发育不良、免疫缺陷的婴幼儿RSV病死率率高达5%,造成严重的医疗负担。 RSV无安全、有效疫苗上市,唯一获准上市的预防性RSV药物为中和性单抗palivizumab(Synagis®),特异性识别RSV融合蛋白。Syn...; Respiratory syncytial virus (RSV) is one of major pathogens for lower respiratory tract infection. It has a large infected age distribution, including almost all the population from the newborn to the elderly. It is reported that almost all children under two-year old have been infected by RSV. Hospitalization of infants due to RSV infections is 2.5-4% each year. Data from a variety of studies sug...; 学位:医学硕士; 院系专业:公共卫生学院_流行病与卫生统计学; 学号:32720131150559 |
语种 | zh_CN |
出处 | http://210.34.4.13:8080/lunwen/detail.asp?serial=56637 |
内容类型 | 学位论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/128546] ![]() |
专题 | 公共卫生-学位论文 |
推荐引用方式 GB/T 7714 | 詹炉停. 呼吸道合胞病毒感染动物模型的建立及应用, Establishment and Application of Respiratory Syncytial Virus Animal Model[D]. 2017, 2016. |
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