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	Preparation and characterization of hydroxycamptothecin-loaded Poly(D,L-lactic acid) nanoparticles with high drug loading capacity
	Hou, ZhenQing ; Zhou, ShuiFan ; Cui, Fei ; Hang, YiXiao ; Yi, YunFeng ; Hou ZQ(侯振清)
	2012
关键词	CAMPTOTHECIN DELIVERY MICROSPHERES FORMULATION
英文摘要	Conference Name:2nd International Conference on Material Engineering, Chemistry, Bioinformatics (MECB 2012). Conference Address: Xian, PEOPLES R CHINA. Time:JUL 14-15, 2012.; Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.
语种	英语
出处	http://dx.doi.org/10.4028/www.scientific.net/AMR.531.503
出版者	ADV MATER RES-SWITZ
内容类型	其他
源URL	[http://dspace.xmu.edu.cn/handle/2288/85103]
专题	材料学院－会议论文
推荐引用方式 GB/T 7714	Hou, ZhenQing,Zhou, ShuiFan,Cui, Fei,et al. Preparation and characterization of hydroxycamptothecin-loaded Poly(D,L-lactic acid) nanoparticles with high drug loading capacity. 2012-01-01.

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