&beta;-环糊精与阿霉素表面包络作用的电化学研究

CORC > 厦门大学 > 2011年第17卷

	β-环糊精与阿霉素表面包络作用的电化学研究; Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin
	石健 ; 张其平 ; 王南平 ; SHI Jian ; ZHANG Qi-Ping ; WANG Nan-Ping
刊名	http://electrochem.xmu.edu.cn/CN/abstract/abstract9830.shtml
	2011-11-28
关键词	阿霉素 &beta -环糊精修饰电极包络 adriamycin &beta -cyclodextrin modified electrode complex
英文摘要	研究了阿霉素（ADM）在β-环糊精（β-CD）修饰金电极上的电化学行为，结果表明，β-CD/Au电极ADM发生表面包络反应。25 ℃，pH=7.0时，该电极表面包络常数为9.54×104 L?mol-1，表面包络常数随温度呈规律性变化，最适宜反应温度为30℃。该电极ADM包络呈准可逆的电化学反应，其速率常数为0.0995 s-1。在20~40 μmol?L-1浓度范围β-CD/Au电极ADM的还原峰电流与浓度呈线性关系，线性方程 Ip=2.024+0.0057C，相关系数0.9911，检出限6.5 μmol?L-1。; The β-cyclodextrin (β-CD) modified gold electrode (β-CD/Au) was fabricated to study the electrochemical behavior of adriamycin (ADM). The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface. At 25 ℃，the complexing constant (K) was 9.54×104 L?mol-1 in pH=7.0. The K values changed regularly with temperature, and the most suitable temperature of the surface inclusion reaction was 30 ℃. The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1. The cathodic peak current (Ip) of ADM was proportional to the concentration of ADM in the 20~40 μmol?L-1. The linear regression equation for the quantitative determination of ADM concentration (C) by β-CD/Au was Ip=2.024+0.0057C with a correlation coefficient of 0.9911. The detection limit was 6.5 μmol?L-1.; 作者联系地址：南通大学化学化工学院，南通 226007; Author's Address: School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007, Jiangsu China; 通讯作者E-mail：bobow56@163.com
语种	中文
出版者	厦门大学《电化学》编辑部
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/58455]
专题	2011年第17卷
推荐引用方式 GB/T 7714	石健,张其平,王南平,等. β-环糊精与阿霉素表面包络作用的电化学研究, Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin[J]. http://electrochem.xmu.edu.cn/CN/abstract/abstract9830.shtml,2011.
APA	石健,张其平,王南平,SHI Jian,ZHANG Qi-Ping,&WANG Nan-Ping.(2011).β-环糊精与阿霉素表面包络作用的电化学研究.http://electrochem.xmu.edu.cn/CN/abstract/abstract9830.shtml.
MLA	石健,et al."β-环糊精与阿霉素表面包络作用的电化学研究".http://electrochem.xmu.edu.cn/CN/abstract/abstract9830.shtml (2011).