题名 | NFAT2对破骨细胞CAⅡ和V-ATPase基因表达的影响及低频脉冲电磁场的干预研究; NFAT2 in the regulation of CAII and V-ATPase mRNA expression in osteoclast-like cells and intervention study of PEMF |
作者 | 傅继凡 |
答辩日期 | 2017-01-06 ; 2016-05-18 |
导师 | 陈健 |
关键词 | lentiviral pulsed electromagnetic fileds NFATc1 慢病毒 低频脉冲电磁场 活化T细胞核因子1 |
英文摘要 | 目的:研究低频脉冲电磁场(PEMF)对去卵巢大鼠核因子κB受体活化因子(RANK)、活化T细胞核因子(NFATc1/NFAT2)、碳酸酐酶II(CAII)、空泡型H+三磷酸腺苷转运酶(V-ATPase)基因表达的影响;研究NFAT2对CAII和V-ATPase基因表达的调控作用。 方法:1.选取48只雌性SD大鼠,分为三组,分别为SHAM(假手术)组、OVX(去卵巢)组、OVX+PEMF组,OVX+PEMF组随机选一半被PEMF干预14天和28天,测雌激素和骨密度。RT-PCR检测NFAT2、RANK、CAII和V-ATPase基因的表达。 2.设计NFAT2-RNAisiRNA干扰序列,...; Aims:To investigate the effect of pulsed electromagnetic fileds (PEMF) on the expression of several osteoclast-related genes, including RANK、NFATc1 and V-ATPase, in ovariectomized rats; To explore the regulate role of NFAT2 on the expression of CAII and V-ATPase mRNA. Methods: 1.Forty eight female Sprague-Dawley rats were divided into three groups: Sham-operated group (SHAM), Ovariectomy group (...; 学位:医学硕士; 院系专业:医学院_康复医学与理疗学; 学号:24520131153542 |
语种 | zh_CN |
出处 | http://210.34.4.13:8080/lunwen/detail.asp?serial=57216 |
内容类型 | 学位论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/135106] ![]() |
专题 | 医学院-学位论文 |
推荐引用方式 GB/T 7714 | 傅继凡. NFAT2对破骨细胞CAⅡ和V-ATPase基因表达的影响及低频脉冲电磁场的干预研究, NFAT2 in the regulation of CAII and V-ATPase mRNA expression in osteoclast-like cells and intervention study of PEMF[D]. 2017, 2016. |
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