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题名多环芳烃暴露与不良妊娠结局的关系及其机制研究; The study on the association between polycyclic aromatic hydrocarbons exposure and adverse pregnancy outcomes and their mechanisms
作者钟渊福
答辩日期2012 ; 2012
导师左正宏
关键词妊娠结局 多环芳烃 基因多态性 Pregnancy outcome PAHs Gene polymorphism
英文摘要目的通过流行病学调查,掌握闽南地区妊娠妇女妊娠结局情况,并探讨多环芳烃(polycyclicaromatichydrocarbons,PAHs)暴露对妊娠结局的影响,结合PAHs代谢酶活性及基因多态性分析,DNA损伤等指标,评价PAHs暴露对胎儿健康的危害。 方法利用问卷形式收集1106例孕妇流行病学资料,以了解环境因素对妊娠妇女妊娠结局的影响。采用气相色谱串联质谱(gaschromatograph-massspectrometer,GC-MS)技术测定206例孕妇外周静脉血、新生儿脐带血中PAHs含量;应用聚合酶链反应-限制性片段长度多态性(polymerasechainreaction-...; Objective In order to investigate the effect of polycyclic aromatic hydrocarbons (PAHs) exposure on pregnancy outcomes, a questionnaire survey and the level of PAHs in serum of pregnant women and cord blood of newborn were analysis. To elucidate the mechanisms of PAHs exposure on pregnancy outcomes, the metabolic enzyme activity, gene polymorphism, and DNA damage were detected. Methods Using a ...; 学位:理学硕士; 院系专业:生命科学学院生物学系_动物学; 学号:21720091152032
语种zh_CN
出处http://210.34.4.13:8080/lunwen/detail.asp?serial=34393
内容类型学位论文
源URL[http://dspace.xmu.edu.cn/handle/2288/47167]  
专题生命科学-学位论文
推荐引用方式
GB/T 7714
钟渊福. 多环芳烃暴露与不良妊娠结局的关系及其机制研究, The study on the association between polycyclic aromatic hydrocarbons exposure and adverse pregnancy outcomes and their mechanisms[D]. 2012, 2012.
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