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	SBA-15与SBA-16作为药物载体的性能研究; Comparative Study on Improvement of Diabetic Model Rats between SBA-15/GLZ and SBA-16/GLZ
	郑宗富 ; 林赵栋 ; 郑梅淋 ; 洪宇 ; 翁少煌 ; 谭鸿
	2015-06-15
关键词	SBA-15 SBA-16 格列齐特 糖尿病 SBA-15 SBA-16 gliclazide diabetes mellitus
英文摘要	目的:通过建立Sd大鼠2型糖尿病模型的方法,研究不同的介孔材料SAb-15与SAb-16分别载药格列齐特(glz),释放速率的作用,以筛选出最佳的载药系统,为临床制剂提供参考。方法:考察SAb-15/glz、SAb-16/glz的载药、释药性能,建立大鼠糖尿病模型,分别检测灌胃给药前(0H)和给药后各时间点(3 H,6 H,9 H,12 H,24 H,27 H,30 H,48 H)各组大鼠血糖浓度的变化。结果:1载药系统的热重分析,SbA-15/glz、SbA-16/glz在200~700℃均有显著的失重,分别是14.3%和15.4%,且SbA-16/glz失重高于SbA-15/glz;2fTIr分析中,在红外光谱中500 CM-1~2000 CM-1波数范围内两种材料载药均出现了4个吸收强度较大的特征峰,二者波数范围相同,波峰相似,且与glz的分布趋势大致一致,且SbA-16/glz的吸收强度略高于SbA-15/glz;3载药系统的结构性质,与SbA-15比较,SbA-15/glz在比表面积、孔隙容积上均减小(P<0.01),与SbA-16比较,SbA-16/glz比表面积、孔隙容积上均减小,且SbA-16/glz的比表面积、孔隙容积均显著小于SbA-15/glz(P<0.01);4释放速率:SbA-15/glz内格列齐特有一个迅速的释放过程,12 H即达90%以上,24 H后缓释量逐渐趋于平缓,48 H释放量即达到95%以上,最终缓释量约在97%水平;而SbA-16/glz内格列齐特的缓释相对平缓,12 H之内释放了80%左右,显著低于同等时间点SbA-15对格列齐特释放(P<0.05),48 H最终缓释量约在90%的水平;5血糖变化,在0 H测得的血糖结果中,模型组及各给药组的血糖均显著升高,且≥13.8 MMO l/l,说明造模成功;12 H的血糖值最低,随着时间的推移,glz组的血糖变化梯度最大,SbA-15/glz次之,SbA-16/glz血糖值的变化曲线较平坦,说明介孔材料能有效载药、平稳缓释、在动物模型体内平稳持续释药并发挥作用,避免血糖浓度忽高忽低,SbA-16/glz缓释效果显著优于SbA-15/glz。结论:SAb-16介孔材料的载药量高于SAb-15,缓释持续时间长。; Objective: This paper was to research on different mesoporous materials SAB-15 and SAB-16 respectively,the drug loaded Zig Leo Te( GLZ) release rate effect by the method of establishing model of SD rats with type 2 diabetes,and to screen out the best drug carrier-system for clinical use.Methods: Diabetic rat model was established,then to investigate the effect of SAB-15 /GLZ,SBA-16 / GLZ and detect the blood glucose,plasma insulin at the point of 0 h,3 h,6 h,9 h,12 h,24 h,27 h,30 h,48 h.Results: 1The weight analysis system loaded with heat showed that,SBA-15 / GLZ and SBA-16 / GLZ in 200 ~ 700 ℃ showed a significant weight loss,respectively 14.3% and 15.4%,and SBA-16 / G LZ weight loss was higher than that of SBA-15 / GLZ; 2The FTIR analysis,in the IR spectra of 500 cm-1~ 2000 cm-1,wave number range material drug carrier appeared 4 absorption intensity of characteristic peak,and the two peak wave number range is similar,and generally consistent with the distribution of GLZ and SBA-16 / GLZ,the absorption intensity is slightly higher than that of SBA-15 / GLZ; 3The structure properties of the drug carrier system,compared with SBA-15,SBA-15 / GLZ specific surface area,pore volume were reduced( P < 0.01); that compared with SBA-16,SBA-16 / GLZ surface area and porevolume decreased,and the SBA-16 / GLZ specific surface area and pore volume were significantly less than SBA-15 / GLZ( P < 0.01); 4Release rate: SBA-15 to GLZ procedure of a quick release and he quantity achieved above90% at the 12 th h,the rate slowed down after 24 h,at the 48 th h the quantity achieced above 95%,eventually slow release quantity was about 97%.The SBA-16 / GLZ sustained-release relatively flat,within 12 h released by about 80%,significantly lower than SBA-15 at the same point in time( P < 0.05),eventually slow release quantity was about 90%.5The changes of blood glucose showed that,measured at 0thh blood glucose results in the model group and the drug group blood sugar were significantly increased,and was higher than 13.8mmo L / L,indicating a successful model; The glucose concentration of each group at 12 thh was the lowest,and blood glucose in GLZ group change gradient was the biggest,SBA-15 / GLZ group change gradient was less than GLZ group,the curve of change with SBA-16 / GLZ group curve was flat as time went by.Which indicated that be effective,sustained release drug carrier,and played a role in the animal model in vivo sustained drug release and smooth,prevent blood glucose concentration fluctuat,SBA-16 sustained release effect was superior to that of SBA-15.Conclusion: The description of the drug loading of SBA-16 mesoporous material is better than SBA-15 which with releasing of long duration.; 南京军区医药卫生科研基金(编号:08MA115)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/123534]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	郑宗富,林赵栋,郑梅淋,等. SBA-15与SBA-16作为药物载体的性能研究, Comparative Study on Improvement of Diabetic Model Rats between SBA-15/GLZ and SBA-16/GLZ[J],2015.
APA	郑宗富,林赵栋,郑梅淋,洪宇,翁少煌,&谭鸿.(2015).SBA-15与SBA-16作为药物载体的性能研究..
MLA	郑宗富,et al."SBA-15与SBA-16作为药物载体的性能研究".(2015).

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