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	伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病疗效的Meta分析; Therapeutic Efficacy of Itraconazole versus Fluconazole in the Treatment of Vulvovaginal Candidiasis:A Meta-analysis
	陈文婵 ; 余靓平 ; 欧阳华 ; 宋敏 ; 苏美琴 ; 杜瑜
	2014-09-24
关键词	伊曲康唑 氟康唑 Meta分析 外阴阴道念珠菌病 随机对照试验 疗效 Itraconazole Fluconazole Meta-analysis Vulvovaginal candidiasis RCTs Effictiveness
英文摘要	目的:系统评价伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病(VVC)的临床疗效,以为临床提供循证参考。方法:计算机检索PubMEd、EMbASE、MEdlInE、THE COCHrAnE lIbrAry、中文科技期刊数据库、中国期刊全文数据库、万方数据库,收集伊曲康唑对比氟康唑治疗单纯性VVC的随机对照试验(rCT),提取资料后采用rEV MAn 5.2统计软件进行META分析。结果:纳入7项rCT,合计1 006例患者。META分析结果显示,氟康唑组患者总治愈率[Or=0.50,95%CI(0.32,0.79),P=0.003]、第一阶段随访的真菌学治愈率高于伊曲康唑组[Or=0.61,95%CI(0.42,0.89),P=0.01],两组比较差异有统计学意义;两组患者临床治愈率、第二阶段随访的真菌学治愈率以及复发率比较差异无统计学意义。结论:氟康唑治疗单纯性VVC的疗效优于伊曲康唑,可以提高患者的总治愈率和第一阶段随访的真菌学治愈率。由于纳入研究数量较少、质量偏低,该结论尚需大样本、高质量的rCT进一步证实。; OBJECTIVE:To evaluate the clinical efficacy of itraconazole versus fluconazol in the treatment of simple vulvovaginal candidiasis(VVC) systematically and to provide evidence-based reference for clinical use.METHODS:Retrieved from PubMed,EMBase,Medline,The Cochrane Library,VIP,CNKI and Wanfang database,RCT about itraconazole versus fluconazol in the treatment of simple VVC were collected,and Meta-analysis was conducted by using Rev Man 5.2 statistical software after extracting data.RESULTS:A total of 7 RCT were included,involving 1 006 patients.Meta-analysis showed that total cure rate[OR=0.50,95%CI(0.32,0.79),P=0.003] and 1st microbiological cure rate [OR=0.61,95%CI(0.42,0.89),P=0.01] of control group were higher than trial group;there was statistical significance;there was no significant difference in cure rate,2nd microbiological cure rate and recurrence rate between 2 groups.CONCLUSIONS:Itraconazole maybe perform better than fluconazole in the treatment of simple VVC,and can improve cure rate and 1st microbiological cure rate.Due to small-scale and low-quality included studies,the conclusion should be further validated by large-scale and high-quality RCTs.; 国家科技支撑计划子课题(No.2013BAI06B04Y023081)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/123510]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	陈文婵,余靓平,欧阳华,等. 伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病疗效的Meta分析, Therapeutic Efficacy of Itraconazole versus Fluconazole in the Treatment of Vulvovaginal Candidiasis:A Meta-analysis[J],2014.
APA	陈文婵,余靓平,欧阳华,宋敏,苏美琴,&杜瑜.(2014).伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病疗效的Meta分析..
MLA	陈文婵,et al."伊曲康唑对比氟康唑治疗单纯性外阴阴道念珠菌病疗效的Meta分析".(2014).

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