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	口服固体自微乳化给药系统的研究进展; Progress on solid self-microemulsifying drug delivery system for oral administration
	赵佳丽 ; 温许 ; 张晶 ; 刘建清 ; 宋洪涛
	2014-07-25
关键词	固体自微乳化给药系统 固化技术 口服生物利用度 S-SMEDDS solidification technology oral bioavailability
英文摘要	目的对新近发展的固体自微乳化给药系统(S-SMEddS)文献进行综述。方法查阅近年国内外相关文献并进行归纳和总结。结果对固体自微乳的载体、固化技术以及缓控释制剂进行了探讨,为研究水难溶性药物的生物利用度及适合药物释放特性的S-SMEddS技术提供相关参考。结论固体自微乳化系统可以显著提高难溶性药物的口服生物利用度,且兼顾了液态自微乳和固体制剂二者的优势,是一个极具潜力的新型制剂。; Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS).Methods Relevant literatures at home and abroad in recent years were consulted and summarized.Results Solid self-microemulsions carrier,solidification technology and controlled release formulations were discussed,in order to provide relevant references for improving the bioavailability of water-insoluble drugs and the SMEDDS technology for drug release characteristics.Conclusion The utilization of the solid self-emulsifying drug delivery system could significantly enhance the oral bioavailability of water-insoluble drugs.As a new formulation,S-SMEDDS presented huge potential.
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/123477]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	赵佳丽,温许,张晶,等. 口服固体自微乳化给药系统的研究进展, Progress on solid self-microemulsifying drug delivery system for oral administration[J],2014.
APA	赵佳丽,温许,张晶,刘建清,&宋洪涛.(2014).口服固体自微乳化给药系统的研究进展..
MLA	赵佳丽,et al."口服固体自微乳化给药系统的研究进展".(2014).

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