Emerging roles of TEAD transcription factors and its coactivators in cancers

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	Emerging roles of TEAD transcription factors and its coactivators in cancers
	Pobbati, Ajaybabu V. ; Hong, Wanjin ; Hong WJ(洪万进)
刊名	http://dx.doi.org/10.4161/cbt.23788
	2013
关键词	YES-ASSOCIATED PROTEIN SQUAMOUS-CELL CARCINOMA HIPPO-YAP PATHWAY GENE-EXPRESSION BREAST-CANCER NEURAL CREST LUNG-CANCER ENHANCER TAZ ONCOGENE
英文摘要	TEAD proteins are transcription factors that are crucial for development, but also play a role in cancers. Several developmentally and pathologically important genes are upregulated by TEADs. TEADs have a TEA domain that enables them to bind specific DNA elements and a transactivation domain that enables them to interact with coactivators. TEADs on their own are unable to activate transcription and they require the help of coactivators. Several TEAD-interacting coactivators are known and they can be classified into three groups: (1) YAP and its paralog TAZ; (2) Vgll proteins; and (3) p160s. Accordingly, these coactivators also play a role in development and cancers. Recent studies have shown that TEADs and their coactivators aid in the progression of various cancers, including the difficult to treat glioblastoma, liver and ovarian cancers. They facilitate cancer progression through expression of proliferation promoting genes such as c-myc, survivin, Axl, CTGF and Cyr61. There is also a good correlation between high TEAD or its coactivator expression and poor prognosis in various cancers. Given the fact that TEADs and their coactivators need to work together for a functional outcome, disrupting the interaction between them appears to be a viable option for cancer therapy. Structures of TEAD-coactivator complexes have been elucidated and will facilitate drug design and development.
语种	英语
出版者	LANDES BIOSCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93071]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	Pobbati, Ajaybabu V.,Hong, Wanjin,Hong WJ. Emerging roles of TEAD transcription factors and its coactivators in cancers[J]. http://dx.doi.org/10.4161/cbt.23788,2013.
APA	Pobbati, Ajaybabu V.,Hong, Wanjin,&洪万进.(2013).Emerging roles of TEAD transcription factors and its coactivators in cancers.http://dx.doi.org/10.4161/cbt.23788.
MLA	Pobbati, Ajaybabu V.,et al."Emerging roles of TEAD transcription factors and its coactivators in cancers".http://dx.doi.org/10.4161/cbt.23788 (2013).