Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet beta Cell Growth

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	Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet beta Cell Growth
	Zhu, Dan ; Zhang, Yi ; Lam, Patrick P. L. ; Dolai, Subhankar ; Liu, Yunfeng ; Cai, Erica P. ; Choi, Diana ; Schroer, Stephanie A. ; Kang, Youhou ; Allister, Emma M. ; Qin, Tairan ; Wheeler, Michael B. ; Wang, Cheng-Chun ; Hong, Wan-Jin ; Woo, Minna ; Gaisano, Herbert Y. ; Hong WJ(洪万进)
刊名	http://dx.doi.org/10.1016/j.cmet.2012.07.001
	2012-08-08
关键词	GRANULE EXOCYTOSIS MEMBRANE-FUSION GLUT4 TRAFFICKING PANCREATIC-ISLET LATE ENDOSOMES V-SNARE SECRETION ENDOBREVIN/VAMP-8 VAMP8/ENDOBREVIN DUPLICATION
英文摘要	Canadian Institute of Health Research [CIHR] [MOP 89889, MOP 86544, MOP 201188]; Banting and Best Diabetes Centre, University of Toronto; Canadian Diabetes Association; Optimal insulin secretion required to maintain glucose homeostasis is the summation of total pancreatic islet beta cell mass and intrinsic secretory capacity of individual beta cells, which are regulated by distinct mechanisms that could be amplified by glucagon-like-peptide-1 (GLP-1). Because of these actions of GLP-1 on islet beta cells, GLP-1 has been deployed to treat diabetes. We employed SNARE protein VAMP8-null mice to demonstrate that VAMP8 mediates insulin granule recruitment to the plasma membrane, which partly accounts for GLP-1 potentiation of glucose-stimulated insulin secretion. VAMP8-null mice also exhibited increased islet beta cell mass from increased beta cell mitosis, with beta cell proliferative activity greatly amplified by GLP-1. Thus, despite the beta cell exocytotic defect, VAMP8-null mice have an increased total insulin secretory capacity, which improved glucose homeostasis. We conclude that these VAMP8-mediated events partly underlie the therapeutic actions of GLP-1 on insulin secretion and beta cell growth.
语种	英语
出版者	CELL METAB
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93064]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	Zhu, Dan,Zhang, Yi,Lam, Patrick P. L.,et al. Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet beta Cell Growth[J]. http://dx.doi.org/10.1016/j.cmet.2012.07.001,2012.
APA	Zhu, Dan.,Zhang, Yi.,Lam, Patrick P. L..,Dolai, Subhankar.,Liu, Yunfeng.,...&洪万进.(2012).Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet beta Cell Growth.http://dx.doi.org/10.1016/j.cmet.2012.07.001.
MLA	Zhu, Dan,et al."Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet beta Cell Growth".http://dx.doi.org/10.1016/j.cmet.2012.07.001 (2012).