Ultra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy

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	Ultra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy
	Song, Xuejiao ; Gong, Hua ; Yin, Shengnan ; Cheng, Liang ; Wang, Chao ; Li, Zhiwei ; Li, Yonggang ; Wang, Xiaoyong ; Liu, Gang ; Liu, Zhuang ; Liu G(刘刚)
刊名	http://dx.doi.org/10.1002/adfm.201302463
	2014
关键词	NEAR-INFRARED ABSORBENCY MAGNETIC NANOPARTICLES GOLD NANOCAGES CANCER-THERAPY BIOMEDICAL APPLICATIONS POLYMER NANOPARTICLES CONDUCTING POLYMER CONTRAST AGENTS GRAPHENE OXIDE TISSUE
英文摘要	National Natural Science Foundation of China [51222203, 51002100, 51132006]; National "973" Program of China [2012CB932601, 2013CB932702, 2011CB911002]; Priority Academic Program Development of Jiangsu Higher Education Institutions; Post-doctoral research program of Jiangsu Province [1202044C]; Recently, near-infrared (NIR) absorbing conjugated polymeric nanoparticles have received significant attention in photothermal therapy of cancer. Herein, polypyrrole (PPy), a NIR-absorbing conjugate polymer, is used to coat ultra-small iron oxide nanoparticles (IONPs), obtaining multifunctional IONP@PPy nanocomposite which is further modified by the biocompatible polyethylene glycol (PEG) through a layer-by-layer method to acquire high stability in physiological solutions. Utilizing the optical and magnetic properties of the yielded IONP@PPy-PEG nanoparticles, in vivo magnetic resonance (MR) and photoacoustic imaging of tumor-bearing mice are conducted, revealing strong tumor uptake of those nanoparticles after intravenous injection. In vivo photothermal therapy is then designed and carried out, achieving excellent tumor ablation therapeutic effect in mice experiments. These results promise the use of multifunctional NIR-absorbing organic-inorganic hybrid nanomaterials, such as IONP@PPy-PEG presented here, for potential applications in cancer theranostics.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87591]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Song, Xuejiao,Gong, Hua,Yin, Shengnan,et al. Ultra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy[J]. http://dx.doi.org/10.1002/adfm.201302463,2014.
APA	Song, Xuejiao.,Gong, Hua.,Yin, Shengnan.,Cheng, Liang.,Wang, Chao.,...&刘刚.(2014).Ultra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy.http://dx.doi.org/10.1002/adfm.201302463.
MLA	Song, Xuejiao,et al."Ultra- Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy".http://dx.doi.org/10.1002/adfm.201302463 (2014).