Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging | |
Xing, Ruijun ; Liu, Gang ; Zhu, Jinghan ; Hou, Yanglong ; Chen, Xiaoyuan ; Liu G(刘刚) ; Chen XY(陈小元) | |
刊名 | http://dx.doi.org/10.1007/s11095-013-1205-2
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2014 | |
关键词 | IRON-OXIDE NANOPARTICLES SMALL INTERFERING RNA LOW-MOLECULAR-WEIGHT IN-VIVO DRUG-DELIVERY PAMAM DENDRIMERS BIOMEDICAL APPLICATIONS SURFACE MODIFICATION DNA DELIVERY TRANSFECTION EFFICIENCY |
英文摘要 | Major State Basic Research Development Program of China (973 Program) [2010-CB934601, 2013CB733802]; National Nature Science of Foundation of China (NSFC) [81101101, 51273165, 51125001, 51172005]; National Natural Science Foundation of China [51250110078]; Fundamental Research Funds for the Central Universities [2013121039]; Chinese Ministry of Education [212149]; Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable size, and excellent magnetic properties, make them promising candidates for gene delivery. The engineered MNPs with modifiable functional surfaces and bioactive cores can result in several advantageous diagnostic and therapeutic properties including enhanced magnetic resonance imaging (MRI) signal intensity, long permeation and retention in the circulatory system, specific delivery of therapeutic genes to target sites. In this review, the updated research on the preparation and surface modification of MNPs for gene delivery is summarized. |
语种 | 英语 |
出版者 | SPRINGER/PLENUM PUBLISHERS |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/87582] ![]() |
专题 | 公共卫生-已发表论文 |
推荐引用方式 GB/T 7714 | Xing, Ruijun,Liu, Gang,Zhu, Jinghan,et al. Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging[J]. http://dx.doi.org/10.1007/s11095-013-1205-2,2014. |
APA | Xing, Ruijun.,Liu, Gang.,Zhu, Jinghan.,Hou, Yanglong.,Chen, Xiaoyuan.,...&陈小元.(2014).Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging.http://dx.doi.org/10.1007/s11095-013-1205-2. |
MLA | Xing, Ruijun,et al."Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging".http://dx.doi.org/10.1007/s11095-013-1205-2 (2014). |
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