Superoxide-Mediated Protection of Escherichia coli from Antimicrobials

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	Superoxide-Mediated Protection of Escherichia coli from Antimicrobials
	Mosel, Michael ; Li, Liping ; Drlica, Karl ; Zhao, Xilin ; Zhao XL(赵西林)
刊名	http://dx.doi.org/10.1128/AAC.00754-13
	2013
关键词	CELL-DEATH BACTERICIDAL ANTIBIOTICS HYDROXYL RADICALS LETHALITY SOXRS RESISTANCE TOLERANCE BLEOMYCIN MECHANISM TOXICITY
英文摘要	NIH [1-DP2-OD007423, 1-R01-AI 073491]; Antimicrobial lethality is promoted by reactive oxygen species (ROS), such as superoxide, peroxide, and hydroxyl radical. Pretreatment with subinhibitory concentrations of plumbagin or paraquat, metabolic generators of superoxide, paradoxically reduced killing for oxolinic acid, kanamycin, and ampicillin. These pretreatments also reduced an oxolinic acid-mediated ROS surge. Defects in SoxS MarA or AcrB eliminated plumbagin- and paraquat-mediated MIC increases but maintained protection from killing. Thus, superoxide has both protective and detrimental roles in response to antimicrobial stress.
语种	英语
出版者	AMER SOC MICROBIOLOGY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87555]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Mosel, Michael,Li, Liping,Drlica, Karl,et al. Superoxide-Mediated Protection of Escherichia coli from Antimicrobials[J]. http://dx.doi.org/10.1128/AAC.00754-13,2013.
APA	Mosel, Michael,Li, Liping,Drlica, Karl,Zhao, Xilin,&赵西林.(2013).Superoxide-Mediated Protection of Escherichia coli from Antimicrobials.http://dx.doi.org/10.1128/AAC.00754-13.
MLA	Mosel, Michael,et al."Superoxide-Mediated Protection of Escherichia coli from Antimicrobials".http://dx.doi.org/10.1128/AAC.00754-13 (2013).