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Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles
Xing, Ruijun ; Bhirde, Ashwinkumar A. ; Wang, Shouju ; Sun, Xiaolian ; Liu, Gang ; Hou, Yanglong ; Chen, Xiaoyuan ; Liu G(刘刚) ; Chen XY(陈小元)
刊名http://dx.doi.org/10.1007/s12274-012-0275-5
2013
关键词MAGNETIC NANOPARTICLES FE3O4 NANOPARTICLES SOLID TUMORS CANCER DOXORUBICIN RELEASE TUMORIGENESIS MECHANISMS CONTRAST REVERSAL
英文摘要National Basic Research Program of China (973 Program) [2013CB733802, 2010CB934602]; National Science Foundation of China (NSFC) [81101101, 81201086, 81201129, 81201190, 51273165, 51172005, 81028009]; Chinese Academy of Sciences Professorship for Senior International Scientists [2011T2J06]; Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH); China Scholarship Council; Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T (2) MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.
语种英语
出版者TSINGHUA UNIV PRESS
内容类型期刊论文
源URL[http://dspace.xmu.edu.cn/handle/2288/87552]  
专题公共卫生-已发表论文
推荐引用方式
GB/T 7714
Xing, Ruijun,Bhirde, Ashwinkumar A.,Wang, Shouju,et al. Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles[J]. http://dx.doi.org/10.1007/s12274-012-0275-5,2013.
APA Xing, Ruijun.,Bhirde, Ashwinkumar A..,Wang, Shouju.,Sun, Xiaolian.,Liu, Gang.,...&陈小元.(2013).Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles.http://dx.doi.org/10.1007/s12274-012-0275-5.
MLA Xing, Ruijun,et al."Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles".http://dx.doi.org/10.1007/s12274-012-0275-5 (2013).
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