Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds

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	Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds
	Shen, Qirong ; Dai, Yi ; Wang, Guanghui ; Yao, Fei ; Duan, Yinghui ; Chen, Haifeng ; Zhang, Weige ; Zhang, Xiaokun ; Yao, Xinsheng ; Wang GH(王光辉)
刊名	http://dx.doi.org/10.1016/j.bmc.2014.03.024
	2014-05-01
关键词	FORMOSUM SSP PRUNIFLORUM GAMMA-PYRONE COMPOUNDS XANTHONE DERIVATIVES GARCINIA-MANGOSTANA INHIBITORY-ACTIVITY STEMS RAR
英文摘要	National Natural Science Foundation of China [NSFC-30973614, NSFC-30873146]; Neriifolone B (1), a natural product containing a novel 4',4'-dimethyl-4',5'-dihydropyran-6-one[2',3':3,4]xanthone skeleton, was found to be a potent inhibitor of transcription mediated by retinoid X receptor alpha (RXR alpha). The first total synthesis of neriifolone B (1) was achieved in 14 steps with an overall yield of 7.1%. A Claisen rearrangement was employed as the key step in the sequence. The activity of six natural xanthones and eight compounds related to neriifolone B (1) against RXR alpha-mediated transcription was evaluated. Two neriifolone B analogs, 17 and 11 '', were potent inhibitors of RXR alpha transcriptional activity. Preliminary structure-activity relationship studies are discussed briefly. (C) 2014 Published by Elsevier Ltd.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90936]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Shen, Qirong,Dai, Yi,Wang, Guanghui,et al. Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds[J]. http://dx.doi.org/10.1016/j.bmc.2014.03.024,2014.
APA	Shen, Qirong.,Dai, Yi.,Wang, Guanghui.,Yao, Fei.,Duan, Yinghui.,...&王光辉.(2014).Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds.http://dx.doi.org/10.1016/j.bmc.2014.03.024.
MLA	Shen, Qirong,et al."Total synthesis and RXR alpha-mediated transcription studies of neriifolone B and related compounds".http://dx.doi.org/10.1016/j.bmc.2014.03.024 (2014).