The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA(+), CD4(+) and CD8(+) Cell in Intestine of Mice

CORC > 厦门大学 > 生物医学－已发表论文

	The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA(+), CD4(+) and CD8(+) Cell in Intestine of Mice
	Ke, Yanyan ; Liu, Wenjie ; Wang, Zixu ; Dong, Yulan ; Chen, Yaoxing ; Liu WJ(刘文杰)
刊名	http://dx.doi.org/10.3923/ajava.2011.935.943
	2011-09
关键词	IMMUNE-RESPONSES SYSTEM DENERVATION DOPAMINE SUBSETS COLITIS STRESS GAMMA RATS GUT
英文摘要	National Natural Science Foundation of China [30700575, 30871835]; Beijing Natural Science Foundation [6092016]; Chinese Ministry of Education [20100008110022]; program for Cheung Kong Scholars and Innovative Research Team in University of China [IRT0866]; The purpose of this study was to determine the role of sympathetic nerves on distribution of the gut immune-associated cells (Including Intraepithelial Lymphocyte (IEL), mast cell, IgA(+), CD4(+) and CD8(+) cell) in small intestine. A model of chemical sympathectomy in mice was established by intraperitoneal injection of 6-hydroxydopamine (6-OHDA). The gut immune-associated cells were investigated by histology and immunohistochemistry method. This study found that from proximal to distal segments in small intestine of normal mice, the numbers of intraepithelial lymphocyte, IgA(+) and mast cells decreased gradually, whereas CD4(+) and CD8(+) cell number increased gradually. When 6-hydroxydopamine (6-OHDA) was intraperitoneally injected into mice, IEL numbers were significantly decreased in whole small intestines. However, IgA(+) and mast cell numbers decreased merely in the proximal segment while CD4(+) and CD8(+) cell numbers and their ratio reduced mainly in the distal segment. These findings indicated that sympathetic denervation disturbed the patterns of gut immune-associated cell distribution. It would substantiate the thesis of neuro-immune-endocrine and provide the new ideas for the intestinal disease prevention and drug developments.
语种	英语
出版者	ASIAN J ANIM VET ADV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90921]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Ke, Yanyan,Liu, Wenjie,Wang, Zixu,et al. The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA(+), CD4(+) and CD8(+) Cell in Intestine of Mice[J]. http://dx.doi.org/10.3923/ajava.2011.935.943,2011.
APA	Ke, Yanyan,Liu, Wenjie,Wang, Zixu,Dong, Yulan,Chen, Yaoxing,&刘文杰.(2011).The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA(+), CD4(+) and CD8(+) Cell in Intestine of Mice.http://dx.doi.org/10.3923/ajava.2011.935.943.
MLA	Ke, Yanyan,et al."The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA(+), CD4(+) and CD8(+) Cell in Intestine of Mice".http://dx.doi.org/10.3923/ajava.2011.935.943 (2011).