Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro

CORC > 厦门大学 > 生物医学－已发表论文

	Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro
	Chen, Quan Cheng ; Zhang, Wei Yun ; Jin, Wenyi ; Lee, Ik Soo ; Min, Byung-Sun ; Jung, Hyun-Ju ; Na, Minkyun ; Lee, SangMyung ; Bae, KiHwan ; Chen QC(陈全成)
刊名	http://dx.doi.org/10.1055/s-0029-1185944
	2010-01
关键词	ISOLATED RAT ADIPOCYTES DIABETES-MELLITUS CELLS TRANSLOCATION CONSTITUENTS TRANSPORTER QUERCETIN MYRICETIN JAPONICA INHIBIT
英文摘要	Korea Science and Engineering Foundation (KOSEF) [2009-007-4808]; Glucose uptake assay-guided fractionations on the methanol extract of Sophorae Flos led to the isolation of the flavonoids rutin (1), narcissin (2), quercetin (3), tamarixetin (4), and kaempferol (5) and the isoflavonoids cajanin (6), genistein (7), orobol (8), and pratensein (9). Among them, 1, 4, 5, 6, 8, and 9 significantly improved basal glucose uptake in HepG2 cells. Their improving effects were concentration dependent. Compounds 4, 5, 6, and 9 exhibited effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. However, 2, 3, and 7 did not show any improving effects. Stimulating glucose uptake into peripheral cells may be responsible for reducing the level of blood glucose in the circulation. Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs.
语种	英语
出版者	PLANTA MED
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90920]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Chen, Quan Cheng,Zhang, Wei Yun,Jin, Wenyi,et al. Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro[J]. http://dx.doi.org/10.1055/s-0029-1185944,2010.
APA	Chen, Quan Cheng.,Zhang, Wei Yun.,Jin, Wenyi.,Lee, Ik Soo.,Min, Byung-Sun.,...&陈全成.(2010).Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro.http://dx.doi.org/10.1055/s-0029-1185944.
MLA	Chen, Quan Cheng,et al."Flavonoids and Isoflavonoids from Sophorae Flos Improve Glucose Uptake in Vitro".http://dx.doi.org/10.1055/s-0029-1185944 (2010).