QQ客服 官方微博 反馈留言

	Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
	Wang, G. ; Chen, H. F. ; Huang, M. H. ; Wang, N. L. ; Zhang, J. C. ; Zhang, Y. ; Bai, G. R. ; Fong, W. F. ; Yang, M. S. ; Yao, X. S. ; Chen HF(陈海峰)
	2006
关键词	methyl protodioscin G(2)/M arrest apoptosis
英文摘要	Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin 131 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/66039]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Wang, G.,Chen, H. F.,Huang, M. H.,et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells[J],2006.
APA	Wang, G..,Chen, H. F..,Huang, M. H..,Wang, N. L..,Zhang, J. C..,...&陈海峰.(2006).Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells..
MLA	Wang, G.,et al."Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells".(2006).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。