Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells | |
Wang, G. ; Chen, H. F. ; Huang, M. H. ; Wang, N. L. ; Zhang, J. C. ; Zhang, Y. ; Bai, G. R. ; Fong, W. F. ; Yang, M. S. ; Yao, X. S. ; Chen HF(陈海峰) | |
2006 | |
关键词 | methyl protodioscin G(2)/M arrest apoptosis |
英文摘要 | Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin 131 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/66039] ![]() |
专题 | 生物医学-已发表论文 |
推荐引用方式 GB/T 7714 | Wang, G.,Chen, H. F.,Huang, M. H.,et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells[J],2006. |
APA | Wang, G..,Chen, H. F..,Huang, M. H..,Wang, N. L..,Zhang, J. C..,...&陈海峰.(2006).Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.. |
MLA | Wang, G.,et al."Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells".(2006). |
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