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	The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4
	Yu, Z. Q. ; Lin, K. K. ; Bhandari, A. ; Spencer, J. A. ; Xu, X. M. ; Wang, N. ; Lu, Z. X. ; Gill, G. N. ; Roop, D. R. ; Wertz, P. ; Andersen, B. ; Lv ZX(吕忠显)
	2006
关键词	Get-1 LM04 epidermal differentiation epidermal differentiation complex epidermal barrier grainyhead
英文摘要	Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grh13, a conserved mammalian homologue of Grainyhead, which plays important roles in cuticle development in Drosophila. Get-1 interacts with the LIM-only protein LMO4, which is co-expressed in the developing mammalian epidermis. The epidermis of Get-1(-/-) mice showed a severe barrier function defect associated with. impaired differentiation of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesion in the granular layer. The Get-1 mutation affects multiple genes linked to terminal differentiation and barrier function, including most genes of the epidermal differentiation complex. Get-l therefore directly or indirectly regulates a broad array of epidermal differentiation genes encoding structural proteins, lipid metabolizing enzymes and cell adhesion molecules. Although deletion of the LMO4 gene bad no overt consequences for epidermal development, the epidermal terminal differentiation defect in mice deleted for both Get-1 and LMO4 is much more severe than in Get-1(-/-) mice with striking impairment of stratum corneum formation. These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation. (c) 2006 Elsevier Inc. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65991]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Yu, Z. Q.,Lin, K. K.,Bhandari, A.,et al. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4[J],2006.
APA	Yu, Z. Q..,Lin, K. K..,Bhandari, A..,Spencer, J. A..,Xu, X. M..,...&吕忠显.(2006).The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4..
MLA	Yu, Z. Q.,et al."The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4".(2006).

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