QQ客服 官方微博 反馈留言

	--（131）Ⅰ－McAhJHⅢ对裸鼠荷人肝细胞癌的放射免疫显像研究; Radioimmunoimaging of ￣(131)Ⅰ-Labeled MonoclonalAntibody JHⅢ in Nude Mice Bearing HumanHepatocellular Carcinoma
	苏金华 ; 颜江华 ; 李东辉 ; 杨善民 ; 俞浩 ; 盛荣宗
	1995
关键词	肝细胞癌 单克隆抗体 裸鼠 放射免疫显像 Hepatocellular carcinoma Monoclonal antibody Nude mice Radioimmunoimaging
英文摘要	用氯胺T法标记抗人肝癌单克隆抗体（MCAbJHⅢ），对荷人肝细胞癌bEl-7402裸鼠进行体内生物学分布和肿瘤放射免疫显像研究。腹腔注射131Ⅰ-MCAbJHⅢ后24~120H，肿瘤部位的放射性浓聚，以72~96H的影像最为清晰；而注射131Ⅰ-MIgg则呈全身性均匀分布，无肿瘤部位选择性浓聚现象。131Ⅰ-MCAbJHⅢ注射后72H，13种器官的肿瘤组织与非瘤组织的放射性比值均大于5，肿瘤的定位指数为7.07。这表明MCAbJHⅢ在肝细胞癌的诊断和导向治疗方面可能有较好的应用价值。; he monoclonal antibody JHⅢ (McAbJHⅢ ) against human hepatocellular carcinoma was radiolabeled with 131I by Ch-T method.Its distribution and radioimmnunoimaging in the nude mice bearing human hepatoma BEL-7402 were studied.Between 24-120 h aFter intraperitoneal administration, the image of the concentrating radioactivity in tumor was obtained by the y camera and it was the clearest during 72-96 h;whereas the injection of 131I-mIgG into the nude mice resulted in an equal distribution in the whole body without any selectivity.At 72 haFter the injection of 131I-McAb JHⅢ, the radioactivity ratioes of tumor/normal tissue (T/NT) For 13 kinds of organ/tissue were all over 5, and the localization index of tumor was 7.07.These results showed that McAbJHⅢ may be used in the localization and targeting treatment of human hepatocellular carcinoma.; 福建省计委与卫生厅“八五”攻关课题
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/127233]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	苏金华,颜江华,李东辉,等. --（131）Ⅰ－McAhJHⅢ对裸鼠荷人肝细胞癌的放射免疫显像研究, Radioimmunoimaging of ￣(131)Ⅰ-Labeled MonoclonalAntibody JHⅢ in Nude Mice Bearing HumanHepatocellular Carcinoma[J],1995.
APA	苏金华,颜江华,李东辉,杨善民,俞浩,&盛荣宗.(1995).--（131）Ⅰ－McAhJHⅢ对裸鼠荷人肝细胞癌的放射免疫显像研究..
MLA	苏金华,et al."--（131）Ⅰ－McAhJHⅢ对裸鼠荷人肝细胞癌的放射免疫显像研究".(1995).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。