丝裂霉素C血管外漏致皮肤溃疡的防护实验; An experimental investigation on preventive measures of skin ulcers induced by extravascular Mitomycin C | |
王光华 ; 陈梅 ; 张小谦 ; 陈锦辉 ; 杨善民 ; 陈福 | |
1995 | |
关键词 | 二甲基亚砜 丝裂霉素C 外漏 溃疡防护 Antineoplastic agents Mitomycin C extravasation Dimethyl sulFoxide Prevention of ulcer |
英文摘要 | 为探讨丝裂霉素C实验性血管外漏致皮肤溃疡的防护措施,我们以0.1Mg丝裂霉素C皮下注射bAlb/C小鼠后腿部,制成丝裂霉素C血管外漏性皮肤溃疡模型。在这模型上经8种不同药物或物理措施单独处理后10天所产生的皮肤溃疡面积与对照组(生理盐水封闭)相比较(经T检验后),差异有显著性的组分别是:外漏后及时用0.1Ml99%二甲基亚砜局部封闭或加用它在外漏表皮处外涂(P<0.001),0.1Ml5%碳酸氢钠(P<0.001),0.1Ml1%普鲁卡因(内含0.4%地塞米松)(P<0.001),0.1Ml90%二甲基亚砜(内含10%维生素E)外涂(P<0.01);外漏后半小时用0.1Ml99%二甲基亚砜封闭所产生的皮肤溃疡面积与对照组相比虽有显著差异(P<0.05),但溃疡防护能力较差。冰水冷敷或0.1Ml10%硫代硫酸钠(及时封闭)组与对照组相比差异无显著性(P>0.05)。本研究为临床上丝裂霉素C血管外漏的防护提供了药物选择的依据,文中还讨论了二甲基亚砜对丝裂霉素C外漏性皮肤溃疡防护的机理。; in order to make an investigation on skin ulcer induced by Mitomycin C extravasation, the preventive measures were undergone by the Following ex-periment.A subcutaneous ulcerative model induced by 0.1mg Mitomycin C(MMC)extravasation in the leg of BALA/C mice was established.On the model subject, 8 pharmacologic adjuvants or physical modulation were adopted.It is preFerential to choose local injection with 0.1ml 99% dimethyl sulFoxide(DMSO),or with additional smearing DMSO on the aFFected skin.10 days later, the ulcerative areas with DMSO treatment were signiFicantly decreased in contrast with 0.1 ml 0.9% NaCI treatment (P<0.001).The other preFerential treatment were in turn by the injection of 0.1 ml 5% NaHCO3 (P<0.001); 0.1 ml 1% procainamidi hydrochloridum(including 0.4 % dexame-thasonum) (P<0.001) or smearing with 0.1 ml 90% DMSO (including 10% Vit E) (P<0.01).Delayed application of DMSO aFter MMC extravasation 30 min had been proven the limited eFFects on the prevention of ulcer (P<0.05).Neither cooling of skin or local injection of sodium thiosulFate reduced MMC ulceration (P>0.05) .The mechanisms of prevention of MMC extravascular ulcer by DMSO or 5%NaHCO3 were brieFly discussed |
语种 | zh_CN |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/123639] ![]() |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | 王光华,陈梅,张小谦,等. 丝裂霉素C血管外漏致皮肤溃疡的防护实验, An experimental investigation on preventive measures of skin ulcers induced by extravascular Mitomycin C[J],1995. |
APA | 王光华,陈梅,张小谦,陈锦辉,杨善民,&陈福.(1995).丝裂霉素C血管外漏致皮肤溃疡的防护实验.. |
MLA | 王光华,et al."丝裂霉素C血管外漏致皮肤溃疡的防护实验".(1995). |
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