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	丝裂霉素C血管外漏致皮肤溃疡的防护实验; An experimental investigation on preventive measures of skin ulcers induced by extravascular Mitomycin C
	王光华 ; 陈梅 ; 张小谦 ; 陈锦辉 ; 杨善民 ; 陈福
	1995
关键词	二甲基亚砜 丝裂霉素C 外漏 溃疡防护 Antineoplastic agents Mitomycin C extravasation Dimethyl sulFoxide Prevention of ulcer
英文摘要	为探讨丝裂霉素C实验性血管外漏致皮肤溃疡的防护措施，我们以0.1Mg丝裂霉素C皮下注射bAlb/C小鼠后腿部，制成丝裂霉素C血管外漏性皮肤溃疡模型。在这模型上经8种不同药物或物理措施单独处理后10天所产生的皮肤溃疡面积与对照组（生理盐水封闭）相比较（经T检验后），差异有显著性的组分别是：外漏后及时用0.1Ml99%二甲基亚砜局部封闭或加用它在外漏表皮处外涂（P＜0.001），0.1Ml5%碳酸氢钠（P＜0.001），0.1Ml1%普鲁卡因（内含0.4%地塞米松）（P＜0.001），0.1Ml90%二甲基亚砜（内含10%维生素E）外涂（P＜0.01）；外漏后半小时用0.1Ml99%二甲基亚砜封闭所产生的皮肤溃疡面积与对照组相比虽有显著差异（P＜0.05），但溃疡防护能力较差。冰水冷敷或0.1Ml10%硫代硫酸钠（及时封闭）组与对照组相比差异无显著性（P＞0.05）。本研究为临床上丝裂霉素C血管外漏的防护提供了药物选择的依据，文中还讨论了二甲基亚砜对丝裂霉素C外漏性皮肤溃疡防护的机理。; in order to make an investigation on skin ulcer induced by Mitomycin C extravasation, the preventive measures were undergone by the Following ex-periment.A subcutaneous ulcerative model induced by 0.1mg Mitomycin C(MMC)extravasation in the leg of BALA/C mice was established.On the model subject, 8 pharmacologic adjuvants or physical modulation were adopted.It is preFerential to choose local injection with 0.1ml 99% dimethyl sulFoxide(DMSO),or with additional smearing DMSO on the aFFected skin.10 days later, the ulcerative areas with DMSO treatment were signiFicantly decreased in contrast with 0.1 ml 0.9% NaCI treatment (P<0.001).The other preFerential treatment were in turn by the injection of 0.1 ml 5% NaHCO3 (P<0.001); 0.1 ml 1% procainamidi hydrochloridum(including 0.4 % dexame-thasonum) (P<0.001) or smearing with 0.1 ml 90% DMSO (including 10% Vit E) (P<0.01).Delayed application of DMSO aFter MMC extravasation 30 min had been proven the limited eFFects on the prevention of ulcer (P<0.05).Neither cooling of skin or local injection of sodium thiosulFate reduced MMC ulceration (P>0.05) .The mechanisms of prevention of MMC extravascular ulcer by DMSO or 5%NaHCO3 were brieFly discussed
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/123639]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	王光华,陈梅,张小谦,等. 丝裂霉素C血管外漏致皮肤溃疡的防护实验, An experimental investigation on preventive measures of skin ulcers induced by extravascular Mitomycin C[J],1995.
APA	王光华,陈梅,张小谦,陈锦辉,杨善民,&陈福.(1995).丝裂霉素C血管外漏致皮肤溃疡的防护实验..
MLA	王光华,et al."丝裂霉素C血管外漏致皮肤溃疡的防护实验".(1995).

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