Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties | |
Yin, Dengke ; Wu, Hua ; Liu, Chaoxu ; Zhang, Jun ; Zhou, Ting ; Wu, Jingjing ; Wan, Ying ; Wu H(吴华) ; Zhang J(张军) | |
刊名 | http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017
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2014 | |
关键词 | Cartilage Cell culture Chitosan Collagen Polyesters Repair Tissue |
英文摘要 | Chitosan-polylactide (CH-PLA) copolymers with various polylactide percentages changing from around 14 to 40 wt% were synthesized. CH-PLAs were then blended with type-II collagen to fabricate layered collagen/CH-PLA scaffolds that are potentially suitable for the applications in articular cartilage repair. Based on combinatorial processing techniques involving layer-superposition, thermal melting and freeze-drying, two types of stratified collagen/CH-PLA scaffolds were built. The content of collagen inside the scaffolds altered from the top layer to the bottom layer in a trend contrary to that of chitosan. One of them was fabricated using tripolyphosphate (TPP) as a single crosslinker and another type of scaffold was constructed via a dual-crosslinking pathway using TPP and genipin as two crosslinkers in a designated order. These collagen/CH-PLA scaffolds were found to have graded average pore-size and porosity, gradient swelling index and layer-dependent compressive modulus. The resulting scaffolds were thus partially similar to the articular cartilage extracellular matrix in composition, structure and property. In vitro cell culture on some optimized collagen/CH-PLA scaffolds for a period of time up to 3 weeks showed that the scaffolds were able to well support the growth of the seeded cells, suggesting that these collagen/CH-PLA scaffolds have promising potential for articular cartilage repair. ? 2014 Elsevier Ltd. All rights reserved. |
语种 | 英语 |
出版者 | Elsevier |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/93739] ![]() |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Yin, Dengke,Wu, Hua,Liu, Chaoxu,et al. Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties[J]. http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017,2014. |
APA | Yin, Dengke.,Wu, Hua.,Liu, Chaoxu.,Zhang, Jun.,Zhou, Ting.,...&张军.(2014).Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties.http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017. |
MLA | Yin, Dengke,et al."Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties".http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017 (2014). |
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