Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties

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	Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties
	Yin, Dengke ; Wu, Hua ; Liu, Chaoxu ; Zhang, Jun ; Zhou, Ting ; Wu, Jingjing ; Wan, Ying ; Wu H(吴华) ; Zhang J(张军)
刊名	http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017
	2014
关键词	Cartilage Cell culture Chitosan Collagen Polyesters Repair Tissue
英文摘要	Chitosan-polylactide (CH-PLA) copolymers with various polylactide percentages changing from around 14 to 40 wt% were synthesized. CH-PLAs were then blended with type-II collagen to fabricate layered collagen/CH-PLA scaffolds that are potentially suitable for the applications in articular cartilage repair. Based on combinatorial processing techniques involving layer-superposition, thermal melting and freeze-drying, two types of stratified collagen/CH-PLA scaffolds were built. The content of collagen inside the scaffolds altered from the top layer to the bottom layer in a trend contrary to that of chitosan. One of them was fabricated using tripolyphosphate (TPP) as a single crosslinker and another type of scaffold was constructed via a dual-crosslinking pathway using TPP and genipin as two crosslinkers in a designated order. These collagen/CH-PLA scaffolds were found to have graded average pore-size and porosity, gradient swelling index and layer-dependent compressive modulus. The resulting scaffolds were thus partially similar to the articular cartilage extracellular matrix in composition, structure and property. In vitro cell culture on some optimized collagen/CH-PLA scaffolds for a period of time up to 3 weeks showed that the scaffolds were able to well support the growth of the seeded cells, suggesting that these collagen/CH-PLA scaffolds have promising potential for articular cartilage repair. ? 2014 Elsevier Ltd. All rights reserved.
语种	英语
出版者	Elsevier
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93739]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Yin, Dengke,Wu, Hua,Liu, Chaoxu,et al. Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties[J]. http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017,2014.
APA	Yin, Dengke.,Wu, Hua.,Liu, Chaoxu.,Zhang, Jun.,Zhou, Ting.,...&张军.(2014).Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties.http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017.
MLA	Yin, Dengke,et al."Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties".http://dx.doi.org/10.1016/j.reactfunctpolym.2014.07.017 (2014).