Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles

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	Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles
	Liu, Jin ; Wang, Liqin ; Cao, Jianbo ; Huang, Yue ; Lin, Yu ; Wu, Xiaoyun ; Wang, Zhiyong ; Zhang, Fan ; Xu, Xiuqin ; Liu, Gang ; Liu J(刘静) ; Huang Y(黄悦) ; Zhang F(张帆) ; Xu XQ(徐秀琴) ; Liu G(刘刚)
刊名	http://dx.doi.org/10.1039/c4nr01004c
	2014
关键词	Magnetic resonance imaging Stem cells
英文摘要	Stem cell based therapies offer significant potential in the field of regenerative medicine. The development of superparamagnetic iron oxide (SPIO) nanoparticle labeling and magnetic resonance imaging (MRI) have been increasingly used to track the transplanted cells, enabling in vivo determination of cell fate. However, the impact of SPIO-labeling on the cell phenotype and differentiation capacity of embryonic stem cells (ESCs) remains unclear. In this study, we wrapped SPIO nanoparticles with stearic acid grafted PEI600, termed as Stearic-LWPEI-SPIO, to generate efficient and non-toxic ESC labeling tools. Our results showed that efficient labeling of ESCs at an optimized low dosage of Stearic-LWPEI-SPIO nanoparticles did not alter the differentiation and self-renewal properties of ESCs. The localization of the transplanted ESCs observed by MRI correlated well with histological studies. These findings demonstrate that Stearic-LWPEI-SPIO nanoparticles have potential to be clinically translatable MRI probes and may enable non-invasive in vivo tracking of ESCs in experimental and clinical settings during cell-based therapies. This journal is ? the Partner Organisations 2014.
语种	英语
出版者	Royal Society of Chemistry
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93731]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Jin,Wang, Liqin,Cao, Jianbo,et al. Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles[J]. http://dx.doi.org/10.1039/c4nr01004c,2014.
APA	Liu, Jin.,Wang, Liqin.,Cao, Jianbo.,Huang, Yue.,Lin, Yu.,...&刘刚.(2014).Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles.http://dx.doi.org/10.1039/c4nr01004c.
MLA	Liu, Jin,et al."Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles".http://dx.doi.org/10.1039/c4nr01004c (2014).