Interaction of toxin-1 and T lymphocytes in toxic shock syndrome

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	Interaction of toxin-1 and T lymphocytes in toxic shock syndrome
	Kang, De ; Lin, Cun-he ; Chen, Guixi ; Guo, Shou-gui ; Wu, Yan-sheng ; Zheng, Zhi-peng ; Shi, Cong-hui ; Chen, Gong-lei ; Ji, Xu ; Lin CH(林村河)
刊名	http://dx.doi.org/10.2741/4228
	2014
关键词	CELL-RECEPTOR STAPHYLOCOCCUS-AUREUS CLASS-II IMMUNE-RESPONSES LETHAL SHOCK SUPERANTIGEN ACTIVATION BINDING IDENTIFICATION PROLIFERATION
英文摘要	Toxic shock syndrome (TSS) is a potentially fatal illness caused by infection with the bacterium Staphylococcus aureus. TSS toxin-1 (TSST-1) contains a T-cell epitope with specificity for human V-beta-2. Binding of TSST-1 to the human major histocompatibility complex and T cell receptors activates T cells and triggers the secretion of high amounts of inflammatory cytokines, leading to TSS and potentially death. During this process, CD4(+) T cells are inhibited by TSST-1, while regulatory T cells are increased. This suggests a protective immune response by the body in TSS. Thus, TSST-1 can trigger both, an inflammatory response that attacks the body and a protective response. In this review, we discuss the interaction between TSST-1 and T lymphocytes in TSS.
语种	英语
出版者	FRONTIERS IN BIOSCIENCE INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93714]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Kang, De,Lin, Cun-he,Chen, Guixi,et al. Interaction of toxin-1 and T lymphocytes in toxic shock syndrome[J]. http://dx.doi.org/10.2741/4228,2014.
APA	Kang, De.,Lin, Cun-he.,Chen, Guixi.,Guo, Shou-gui.,Wu, Yan-sheng.,...&林村河.(2014).Interaction of toxin-1 and T lymphocytes in toxic shock syndrome.http://dx.doi.org/10.2741/4228.
MLA	Kang, De,et al."Interaction of toxin-1 and T lymphocytes in toxic shock syndrome".http://dx.doi.org/10.2741/4228 (2014).