Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models | |
Zhao, Yun ; Shu, Ping ; Zhang, Youzhi ; Lin, Limin ; Zhou, Haihong ; Xu, Zhentian ; Suo, Daqin ; Xie, Anzhi ; Jin, Xin ; Zhao Y(赵云) ; Zhou HH(周海虹) ; Jin X(金鑫) | |
刊名 | http://dx.doi.org/10.1155/2014/154295 |
2014 | |
关键词 | HIGH-FAT DIET CHOLESTEROL LEVELS SR-BI RATS HAMSTERS DYSLIPIDEMIA EXTRACT DISEASE LIVER |
英文摘要 | Research Fund of Strait (Xiamen) Technology Platform in Traditional Chinese Medicine [3502Z20100006]; Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties. |
语种 | 英语 |
出版者 | HINDAWI PUBLISHING CORPORATION |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/93703] |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Zhao, Yun,Shu, Ping,Zhang, Youzhi,et al. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models[J]. http://dx.doi.org/10.1155/2014/154295,2014. |
APA | Zhao, Yun.,Shu, Ping.,Zhang, Youzhi.,Lin, Limin.,Zhou, Haihong.,...&金鑫.(2014).Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models.http://dx.doi.org/10.1155/2014/154295. |
MLA | Zhao, Yun,et al."Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models".http://dx.doi.org/10.1155/2014/154295 (2014). |
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